2,3-ジヒドロ-3β-ヒドロキシピロロ[2,1-b]キナゾリン-9(1H)-オン 化学特性,用途語,生産方法
説明
A further alkaloid present in Adhatoda vasica and Peganum harmala, this base
forms colourless crystals from 95 per cent EtOH. It has [α]
22D - 100° (c 0.5,
CHCL3) and the ultraviolet spectrum has absorption maxima at 227, 272, 302
and 315 mfJ.. The alkaloid yields a series of crystalline salts with mineral acids,
e.g. the hydrochloride, m.p. 232-4°C; hydro bromide, m.p. 254-5°C (dec.);
hydriodide, m.p. 222-6°C (dec.); nitrate, m.p. 138-9° C (dec.) and the sulphate,
m.p. l82-5°C (dec.). The optically inactive form of the base has been prepared
synthetically, m.p. 211- 2°C. The alkaloid is an active bronchodilator.
参考文献
Ghose et al., J. Chem. Soc., 2740 (1932)
Morris, Horford, Adams., J. Amer. Chem. Soc., 57,951 (1935)
Mehta, Naravane, Desai., J. Org. Chem., 28, 445 (1963)
2,3-ジヒドロ-3β-ヒドロキシピロロ[2,1-b]キナゾリン-9(1H)-オン 上流と下流の製品情報
原材料
準備製品