(R,S)-AM1241
(R,S)-AM1241 物理性質
- 沸点 :
- 630.7±55.0 °C(Predicted)
- 比重(密度) :
- 1.60±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO: 60°Cで~18mg/mL
- 酸解離定数(Pka):
- 9.73±0.10(Predicted)
- 外見 :
- 個体
- 色:
- 黄色
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
 
|
| 注意喚起語 |
危険 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H334 |
吸入するとアレルギー、喘息または、呼吸困難 を起こすおそれ |
感作性、呼吸器 |
1 |
危険 |
|
P261, P285, P304+P341, P342+P311,P501 |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P302+P352 |
皮膚に付着した場合：多量の水と石鹸で洗うこと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
(R,S)-AM1241 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
Sigma-Aldrich Japan
|
A6478 |
≥98% (HPLC), solid
(R,S)-AM1241 ≥98% (HPLC), solid |
444912-48-5 |
5mg |
￥57500 |
2018-12-25 |
購入 |
|
Sigma-Aldrich Japan
|
A6478 |
≥98% (HPLC), solid
(R,S)-AM1241 ≥98% (HPLC), solid |
444912-48-5 |
25mg |
￥195900 |
2018-12-25 |
購入 |
(R,S)-AM1241 化学特性,用途語,生産方法
説明
AM1241 is a cannabinoid (CB) receptor agonist that is selective for CB
2 over CB
1 with K
i values of 7.1 and 580 nM for human recombinant receptors transfected into HEK and CHO cells, respectively, in a radioligand binding assay. It is considered a protean agonist as it has neutral antagonist and partial agonist activity, depending on the assay utilized. It is also acts in a species-dependent manner
in vitro, acting as an agonist at human CB
2 receptors (EC
50 = 190 nM) but an inverse agonist at rat and mouse CB
2 receptors (EC
50s = 216 and 463 nM, respectively). AM1241 produces antinociception to thermal stimuli in rat hindpaw. The antinociceptive actions of AM1241 were blocked by the CB
2 receptor-selective antagonist AM630 but not by the CB
1 receptor-selective antagonist AM251 . AM1241 is neuroprotective, preventing HIV-1 glycoprotein Gp120-induced apoptosis in primary human and murine neural progenitor cells and increasing cell survival and differentiation. It increases hippocampal neurogenesis and decreases astro- and gliogenesis in GFAP/Gp120 transgenic mice when administered at a dose of 10 mg/kg daily for ten days. AM1241 also delays motor impairment in a murine model of amytrophic lateral sclerosis (ALS).
使用
(2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone is a compound from the aminkalkylindole family which exerts potent and selective agonist activity for the cannabinoid
receptor CB2.
Biochem/physiol Actions
AM1241 acts as an antinociceptive agent in several animal pain models. It has a potential to delay disease progression in amyotrophic lateral sclerosis (ALS) mouse model. Intrathecal, intravenous or intraperitoneal administration of AM1241 reduces hyperalgesia and allodynia in neuropathic rats.
(R,S)-AM1241 上流と下流の製品情報
原材料
準備製品
(R,S)-AM1241 生産企業
Global( 54)Suppliers
444912-48-5()キーワード:
- 444912-48-5
- (R,S)-AM1241
- (R,S)-3-(2-Iodo-5-nitrobenzoyl)-1-(1-methyl-2-piperidinylmethyl)-1H-indole
- (3-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
- (2-Iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-Indol-3-yl)methanone
- (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
- (2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone
- AM1241
(AM-1241
- (R,S)-AM1241 USP/EP/BP
- Methanone, (2-iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]-