カリンドール塩酸塩 化学特性,用途語,生産方法
説明
Calindol is a phenylalkylamine calcimimetic that facilitates the activation of the calcium-sensing receptor (CaSR), a G protein-
coupled receptor that triggers phosphatidylinositol (PI)-intracellular calcium signaling and, in some cell types, cell proliferation. It potently stimulates PI hydrolysis and proliferation through human CaSR (pEC
50 values are 6.9 and 7.4, respectively) in the presence of calcium. Calindol directly interacts with CaSR in transmembrane domains and triggers PI hydrolysis less effectively in the absence of calcium, indicating that it is an allosteric modulator that cooperates with calcium to activate the CaSR. Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues.
化学的特性
Off-White Solid
使用
A new calcimimetic acting at the calcium sensing receptor; a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted Rhodopsin-like seven-transmembrane structure in the absence of Ca2+.
カリンドール塩酸塩 上流と下流の製品情報
原材料
準備製品