7-クロロ-6-デメチルテトラサイクリン 化学特性,用途語,生産方法
効能
抗生物質, タンパク質合成阻害薬
説明
Demethylchlortetracycline was isolated from the culture broth of a mutant of Streptomyces aureofaciens, the chlortetracycline-producing strain, by Lederle Research Laboratories in 1957. It shows one and one-half to two times as much in vitro antimicrobial activity and in vivo protective effect as tetracycline. Its base and hydrochloride have been used orally and by topical application to treat infections caused by Staphylococcus, Streptococcus, Rickettsia, Chlamydiae, Neisseria, Klebsiella, Proteus, Escherichia coli, and Haemophilus influenzae.
使用
Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature with over 800 references relating almost exclusively to in vivo use.
定義
ChEBI: Tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood lev
ls are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) w
ere fluid restriction alone has been ineffective.
安全性プロファイル
Poison by intravenous
and intraperitoneal routes. Human systemic
effects by ingestion: diabetes insipidus, urine
volume increase, other changes in urine
composition, dermatitis, changes in the
nails, allergic rhinitis, serum sickness, effects
on cyclic nucleotides. Human reproductive
effects by an unspecified route: postnatal
measures or effects on newborn. An
experimental teratogen. Experimental
reproductive effects. Human mutation data
reported. When heated to decomposition it
emits very toxic fumes of Cland NOx.
7-クロロ-6-デメチルテトラサイクリン 上流と下流の製品情報
原材料
準備製品