데클로사이클린

데클로사이클린
데클로사이클린 구조식 이미지
카스 번호:
127-33-3
한글명:
데클로사이클린
동의어(한글):
데클로사이클린
상품명:
demeclocycline
동의어(영문):
D03680;Deganol;10192 RP;RP 10192;Demeclor;Mexocine;Diuciclin;Sumaclina;Ledermycin;Elkamicina
CBNumber:
CB5918843
분자식:
C21H21ClN2O8
포뮬러 무게:
464.85
MOL 파일:
127-33-3.mol
MSDS 파일:
SDS

데클로사이클린 속성

녹는점
176°C (rough estimate)
끓는 점
787.1±60.0 °C(Predicted)
밀도
1.3118 (rough estimate)
굴절률
1.6000 (estimate)
용해도
H2O:1.5(Max Conc. mg/mL);3.23(Max Conc. mM)
물리적 상태
Solid
산도 계수 (pKa)
4.50±1.00(Predicted)
색상
Green to dark green
수용성
1.4g/L(25℃)

안전

유해 물질 데이터 127-33-3(Hazardous Substances Data)
기존화학 물질 KE-05618

데클로사이클린 C화학적 특성, 용도, 생산

개요

Demethylchlortetracycline was isolated from the culture broth of a mutant of Streptomyces aureofaciens, the chlortetracycline-producing strain, by Lederle Research Laboratories in 1957. It shows one and one-half to two times as much in vitro antimicrobial activity and in vivo protective effect as tetracycline. Its base and hydrochloride have been used orally and by topical application to treat infections caused by Staphylococcus, Streptococcus, Rickettsia, Chlamydiae, Neisseria, Klebsiella, Proteus, Escherichia coli, and Haemophilus influenzae.

용도

Demeclocycline, a chlortetracycline analogue produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, demeclocycline shows broad spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature with over 800 references relating almost exclusively to in vivo use.

정의

ChEBI: Tetracycline which lacks the methyl substituent at position 7 and in which the hydrogen para- to the phenolic hydroxy group is substituted by chlorine. Like tetracycline, it is an antibiotic, but being excreted more slowly, effective blood lev ls are maintained for longer. It is used (mainly as the hydrochloride) for the treatment of Lyme disease, acne and bronchitis, as well as for hyponatraemia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) w ere fluid restriction alone has been ineffective.

Safety Profile

Poison by intravenous and intraperitoneal routes. Human systemic effects by ingestion: diabetes insipidus, urine volume increase, other changes in urine composition, dermatitis, changes in the nails, allergic rhinitis, serum sickness, effects on cyclic nucleotides. Human reproductive effects by an unspecified route: postnatal measures or effects on newborn. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

데클로사이클린 준비 용품 및 원자재

원자재

준비 용품


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