アジマリン 化学特性,用途語,生産方法
解説
アジュマリン．キョウチクトウ科Rauwolfia属serpentinaなどの主として根から得られるインドールアルカロイドの一つ．板状晶．融点158～160 ℃．[α]33D＋128°(クロロホルム)．λmax 247，295 nm(log ε 3.94，3.49．エタノール)．pKa1 7.64±0.70，pKa2 13.78±0.70．血圧降下薬，鎮静および催眠薬として用いられる．
効能
抗不整脈薬, ナトリウムチャネル遮断薬
説明
Rauwolfia (Luo Fu Mu) is derived from the plants Rauvolfia verticillata (Lour.)
Baill. and R. yunnanensis Tsiang, and the root is usually used as its medicinal part.
R. verticillata (Lour.) Baill. var. hainanensis Tsiang and R. vomitoria Afzel. ex
Spreng have been also used as traditional Chinese herb.
Rauwolfia is one of the important traditional herbs in southern China. Its scope
of treatment includes cold, fever, sore throat, headache, and dizziness caused by
hypertension, abdominal pain and diarrhea, scabies, and so on. Rauwolfia is also
used to treat insomniac dizziness, bruises, sprains, and venomous snake bites in
folk.
In the “Flora of China,” 135 species of Rauwolfia were recorded, mostly distributed in the tropics and subtropics, a few in the temperate regions. There are nine
species, four varieties, and three cultivated species in China.
化学的特性
White Solid
物理的性質
Appearance: white or yellowish crystal powder. Melting point: its anhydride is 205–
207?°C. Optical rotation: +144° (chloroform). Solubility: well soluble in organic
solvents, such as methanol, ethanol, etc., and slightly soluble in water. Storage temperature: 2–8?°C.
来歴
Since 1930s, abundant studies have been focused on the Rauwolfia plants. So far, a
total of 91 alkaloids were separated from Rauwolfia, and the identification of the
chemical structures was obtained, including 2 non-indole alkaloids (thebaine and
papaverine) and 89 indole alkaloids . In accordance with the basic framework,
indole alkaloids can be divided into seven classes, such as the ajmaline class, the
使用
An antiarrhythmic agent isolated from Rauwolfia serpentina.
定義
ChEBI: A monoterpenoid indole alkaloid that consists of ajmalan substituted at positions 17 and 21 by hydroxy groups.
薬理学
Anti-arrhythmic
R. serpentina (She Geng Mu) is the first anti-arrhythmic herbal medicine in the
psychiatry history. Ajmaline has a potent anti-arrhythmic effect for treating atrial and ventricular arrhythmias and also has a good effect on the treatment of
Wolff-Parkinson-White syndrome. Ajmaline plays a main role in decreasing the
permeability of sodium ion on the myocardial cell membrane by moderately inhibiting the sodium channel. The electrophysiological effect of ajmaline is similar to that
of quinidine, but it is stronger than quinidine.
In addition, ajmaline has a mild anti-sympathetic effect. It affects sympathetic
nerve endings to release more sodium, dilate the coronary artery, relax vascular
smooth muscle, and then decrease blood pressure. Therefore, it is suitable for clinical treatment of atrial and ventricular premature beats, pre-excitation syndrome
with supraventricular tachycardia, but not suitable for the treatment of paroxysmal
atrial fibrillation and sinus tachycardia.
臨床応用
Ajmaline has the anti-arrhythmic effects for the treatment of atrial or ventricular
extrasystoles, paroxysmal supraventricular or ventricular tachycardia, and paroxysmal atrial fibrillation. The lethal dose for human ranged from 100 to 500?mg/kg.
純化方法
Ajmaline crystallises from MeOH or EtOAc containing a little H2O to give the trihydrate m 158-160o. This loses 1H2O at 110o and all H2O at 150o. [Beilstein 23 III/IV 3212.]
参考文献
Le Gall., Ann. ph arm. franc., 18,817 (1960)
アジマリン 上流と下流の製品情報
原材料
準備製品