N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド

N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド 化学特性,用途語,生産方法

酵素阻害剤

This potent c-Met protein kinase inhibitor (FW = 539.58 g/mol; CAS 913376-83-7; Solubility: 21 mg/mL DMSO; ~1 mg/mL H2O), also named 1-(2-hydroxy-2-methylpropyl)-N-(5-(7-methoxyquinolin-4-yloxy)pyridin- 2-yl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide, targets the MET proto-oncogene product c-Met, which is the hepatocyte growth factor receptor possessing tyrosine-kinase activity. The primary single-chain precursor protein is posttranslationally cleaved to produce the a and b subunits that are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. AMG-458 preferentially inhibits c-Met (Ki = 1.2 nM), showing ~350-fold greater potency than VEGFR2 in cells. AMG-458 significantly inhibited tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight. AMG 458 binds covalently to liver microsomal proteins from rats and humans, even in the absence of NADPH. When [14C]AMG-458 is incubated with liver microsomes in the presence of glutathione or N-acetyl cysteine, quinolone-type thioether adducts can be detected by radiochromatographyand LC/MS/MS analysis. AMG-458 was more effective in cells that expressed higher levels of c-Met/p-Met, suggesting that higher levels of c- Met and p-Met in non-small cell lung cancer (NSCLC) tissue may classify a subset of tumors that are more sensitive to molecular therapies against this receptor.

N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド 上流と下流の製品情報

原材料

準備製品

N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29798	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	23999	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6008	61
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811783	sales@trio-pharmatech.com (International market)	China	1856	62

913376-83-7(N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド)キーワード:

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• 913376-83-7
• AMG 458
• 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
• 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-
• CS-530
• 1H-Pyrazole-4-carboxamide, 2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-
• AMG 458 USP/EP/BP
• AMG-458 AMG458 c-MET inhibitor
• AMG458,inhibit,Inhibitor,c-Met/HGFR,AMG-458
• AMG458/AMG-458
• N-[5-(7-メトキシ-4-キノリニルオキシ)-2-ピリジニル]-1-(2-ヒドロキシ-2-メチルプロピル)-2-フェニル-3-オキソ-5-メチル-2,3-ジヒドロ-1H-ピラゾール-4-カルボアミド
• 1-(2-ヒドロキシ-2-メチルプロピル)-N-{5-[(7-メトキシキノリン-4-イル)オキシ]ピリジン-2-イル}-5-メチル-3-オキソ-2-フェニル-2,3-ジヒドロ-1H-ピラゾール-4-カルボキサミド