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カプマチニブ

カプマチニブ 化学構造式
1029712-80-8
CAS番号.
1029712-80-8
化学名:
カプマチニブ
别名:
カプマチニブ
英語化学名:
Capmatinib
英語别名:
NC280;CS-192;INC280;INC28060;INCB28060;INCB028060;NVP-INC280;CapMatinib;BenzaMide HCl;Capmatinib base
CBNumber:
CB92574678
化学式:
C23H17FN6O
分子量:
412.42
MOL File:
1029712-80-8.mol

カプマチニブ 物理性質

比重(密度) :
1.40
酸解離定数(Pka):
13.82±0.46(Predicted)

安全性情報

カプマチニブ 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

カプマチニブ 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, 受容体チロシンキナーゼ阻害薬

説明

Capmatinib is a competitive inhibitor with very potent and selective activity against MET compared to other kinases.

説明

INCB 28060 is an inhibitor of heptatocyte growth factor receptor (HGFR, also known as c-Met), potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM). It blocks cell proliferation and migration or induces apoptosis in different types of cancer cells. INCB 28060 is orally bioavailable and inhibits the growth of HGFR-dependent tumors in mice. It also improves efficacy of gemcitabine (Item No. 11690) in a mouse pancreatic cancer model and reduces migration and adhesion in ovarian cancer cell models.

使用

2-Fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide is used in the preparation of a combination formulation with allosteric SHP2 inhibitor TNO155. Used in treatment of non-small cell lung cancer with specific mutations (those that lead to mesenchymal-epithelial transition or MET exon 14 skipping).

副作用

Most common adverse events were nausea, peripheral edema, decreased appetite, rash, and increased amylase and lipase levels.

in vitro

It has been shown in vitro that cell lines made resistant to erlotinib, an EGFR inhibitor, could be resensitized after capmatinib treatment. Results from a phase Ib/II study of patients with EGFR-mutated, MET-dysregulated NSCLC have shown promising responses to a combination of capmatinib and gefitinib (EGFR TKI) following disease progression from an only EGFR TKI treatment regimen. Recommended phase II dose was determined to be capmatinib 400 mg twice/day and gefitinib 250 mg once/day.

カプマチニブ 上流と下流の製品情報

原材料

準備製品


カプマチニブ 生産企業

Global( 217)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Jurong Coupling Biotechnology Co., Ltd.
13656108824
coupling278191416@hotmail.com CHINA 184 58
Nanjing Gold Pharmaceutical Technology Co. Ltd.
025-84209270 15906146951
025-84209270 wgp@nanjing-pharmaceutical.com CHINA 115 55
Suzhou Ryan Pharmachem Technology Co.,Ltd.
0512-68780025-8002
0512-68780025-8004 yybi@ryanchem.com;sales@ryanchem.com CHINA 188 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9150 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58

1029712-80-8(カプマチニブ)キーワード:


  • 1029712-80-8
  • INCB028060
  • CapMatinib (INCB28060)
  • CapMatinib
  • NC280 BenzaMide,2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • NVP-INC280
  • 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide Capmatinib (INCB28060)
  • INCB28060, INC280
  • INC28060
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]- INCB28060
  • INC28060(BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-)
  • INC 280 (INCB28060)
  • INCB28060(Capmatinib)
  • CS-192
  • INCB 28060; INCB-28060; INC280
  • INC280 Capmatinib
  • CAPMATINIB (INC280)
  • BenzaMide INCB28060
  • BenzaMide HCl
  • CAPMATINIB (INCB28060);INCB-28060; INC-280
  • BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-
  • INCB28060
  • 2-Fluoro-N-Methyl-4-(7-quinolin-6-ylMethyl-iMidazo[1,2-b][1,2,4] triazin-2-yl)-benzaMide
  • INC280
  • INCB28060,BenzaMide
  • NC280
  • 2-fluoro-n-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide capmatinib
  • Capmatinib base
  • 2-Fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide
  • Capmatinib USP/EP/BP
  • カプマチニブ
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