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クレソキシムメチル

クレソキシムメチル 化学構造式
143390-89-0
CAS番号.
143390-89-0
化学名:
クレソキシムメチル
别名:
クレソキシムメチル標準品;クレソキシムメチル;メチル=(E)-メトキシイミノ[2-(オルト-トリルオキシメチル)フェニル]アセタート (クレソキシルメチル);メチル=(E)-メトキシイミノ[アルファ-(o-トリルオキシ)-o-トリル]アセタート (別名 クレソキシムメチル);メチル=(E)-2-(メトキシイミノ)-2-{2-[(2-トリルオキシ)メチル]フェニル}アセタート;メチル=(E)-メトキシイミノ[Α-(O-トリルオキシ)-O-トリル]アセタート;クレソキシム‐メチル標準品;クレソキシム-メチル STANDARD;クレソキシム-メチル Standard, 100 µg/mL in Methanol
英語化学名:
Kresoxim-methyl
英語别名:
Cygnus;STROBY;MENTOR;Candit;ALLEGRO;Strob 1;BAS 490F;Stroby WG;RIL-FA 200;BAS 490-02F
CBNumber:
CB6353737
化学式:
C18H19NO4
分子量:
313.35
MOL File:
143390-89-0.mol

クレソキシムメチル 物理性質

融点 :
98-100°C
沸点 :
429.4±47.0 °C(Predicted)
比重(密度) :
1.28
蒸気圧:
2.3 x 10-6 P a (20 °C)
貯蔵温度 :
Inert atmosphere,2-8°C
水溶解度 :
2 mg l-1(20 °C)
外見 :
neat
比重:
1.28 (20℃)
BRN :
8330581
InChIKey:
ZOTBXTZVPHCKPN-HTXNQAPBSA-N
CAS データベース:
143390-89-0(CAS DataBase Reference)
EPAの化学物質情報:
Kresoxim-methyl (143390-89-0)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn;N,N,Xn
Rフレーズ  40-50/53
Sフレーズ  2-36/37-60-61
RIDADR  UN3077 9/PG 3
WGK Germany  3
HSコード  29252900
有毒物質データの 143390-89-0(Hazardous Substances Data)
毒性 LD50 in rats (mg/kg): >5000 orally; >2000 dermally (Ammerman)
PRTR法 第1種指定化学物質
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P273 環境への放出を避けること。
P281 指定された個人用保護具を使用すること。
P501 内容物/容器を...に廃棄すること。

クレソキシムメチル 価格 もっと(7)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-740S クレソキシム-メチル Standard
Kresoxim-methyl Standard, 100 ug/mL in Methanol
143390-89-0 1mL ¥11800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-740N クレソキシムメチル
Kresoxim-methyl
143390-89-0 10mg ¥11800 2021-03-23 購入
関東化学株式会社(KANTO) 49802-91 クレソキシム‐メチル標準品
Kresoxim‐methyl standard
143390-89-0 100mg ¥21000 2021-03-23 購入
Sigma-Aldrich Japan 37899 クレソキシムメチル PESTANAL?, analytical standard
Kresoxim-methyl PESTANAL?, analytical standard
143390-89-0 100mg ¥20300 2021-03-23 購入
林純薬工業株式会社 R1762100 ---
Kresoxim-methyl ---
143390-89-0 100mg ¥15300 2021-03-22 購入

クレソキシムメチル 化学特性,用途語,生産方法

外観

白色~うすい褐色, 結晶性粉末~粉末

溶解性

アセトンに溶け、水にほとんど溶けない。

用途

農薬(殺菌剤)

用途

クレソキシムメチル試験用標準品。

農薬用途

殺菌剤

説明

Kresoxim-methyl is a strobilurin fungicide. It inhibits conidial germination of V. inaequalis isolates from apple orchards (EC50s = 0.00033-0.0078 mg/L). Kresoxim-methyl also inhibits mycelial growth (EC50 = 0.240 mg/L) and is fungicidal against Saprolegnia (MIC = 1 mg/L). It increases intracellular calcium levels and disrupts the mitochondrial membrane potential in mouse cortical cultures in a concentration-dependent manner. Kresoxim-methyl is toxic to goldfish (C. auratus; LC50 = 0.807 mg/L).

使用

Kresoxim-methyl is used for the control of several diseases (scab, mildews, blast, sheath blight and others) on a range of crops including apples, pears, vines, sugar beet and cereals.

使用

An agricultural fungicide.

使用

Agricultural fungicide.

定義

ChEBI: A carboxylic ester that is the methyl ester of (2E)-(methoxyimino){2-[(2-methylphenoxy)methyl]phenyl}acetic acid. A fungicide for the control of scab on apples and pears and other fungal diseases on a wide range of crops.

危険性

Moderately toxic by skin contact. Low tox-icity by ingestion and inhalation.

安全性プロファイル

Moderately toxic by skin contact. Low toxicity by ingestion and inhalation. Questionable carcinogen with experimental data reported. When heated to decomposition it emits toxic vapors of NOx.

代謝経路

By hepatocyte suspensions prepared from goats, pigs, hens, and rats that have been cryopreserved and thawed, BAS 490 F is metabolized via the same pathways as observed using fresh rat hepatocytes. The rate of hydrolysis of 14C-BAS 490 F leading to a carboxylic acid derivative seems to be constant between the cryopreserved and fresh hepatocytes except for goats. The oxidation reaction at the methyl group of the phenoxy ring, leading to the hydroxymethyl analog of the carboxylic acid of BAS 490 F, significantly decreases after cryopreservation, whereas the formation of (E)-2-methoxyimino-2[2-(4- hydroxy-2-methylphenyloxymethyl)phenyl] acetic acid by hydroxylation at the 4-position of the phenoxy ring remains at a constant rate. In pig hepatocytes, the two hydroxylated metabolites of the phenoxy ring, carboxy BAS 409 F and (E)-2-methoxyimino-2-o- hydroxymethylphenyl acetic acid, are formed to a lesser extent after cryopreservation.

代謝

Kresoxim-methyl is rapidly metabolized in mammalian systems to the virtually inactive carboxylic acid, accounting for its low toxicity and high level of selectivity. Atharvest residues in cereals and top fruit are <0.05 mg/kg and <1 mg/kg in grapes and vegetables. The soil DT50 = <3 days, and the Koc is 219 to 372. For the main metabolite, the Koc is 17 to 24. Hydrolytic stability tests indicate a DT50 of 34 days at pH 7 but only 7 h at pH 9.

Toxicity evaluation

Kresoxim-methyl has an acute oral LD50 > 5,000 and an acute dermal LD50 > 2,000 mg/kg in rats. The NOEL for rats is 800 ppm, and the ADI = 0.4 mg/kg bw (body weight). Kresoxim-methyl is not a skin or eye irritant, is nonmutagenic and nonteratogenic. It shows toxicity to aquatic organisms (fish 96-h LC50 = 0.681 to 1 mg/L) but does not cause permanent damage. Other nontarget organisms show the following levels of sensitivity: bird: 14-day LD50 = 2,150 mg/kg; bee: 48- h LD50 ≥ 20 μg/bee; worm: LC50 ≥ 937 mg/kg; Daphnia: 48-h EC50 = 0.186 mg/L; and algae 0- to 2-h EC50 = 63 μg/L.

Degradation

Kresoxim-methyl is a stable crystalline solid with limited water solubility. It is stable in the pH range 3-8 but it is hydrolysed to the carboxylic acid (2, see Scheme 1) in base. DT50 values (25 °C) at pH 5,7 and 9 were 875,34 and 0.29 days, respectively. The product (2) was stable under these conditions.
Kresoxim-methyl undergoes rapid photodegradation in water when irradiated with UV light. Its DT50 was 3 days and several products were formed, one of which was the Z-isomer. Details of the other products are not available. Under conditions of simulated sunlight the compound was degraded with a DT50 of 37 days in pure water and 19 days in natural pond water.

クレソキシムメチル 上流と下流の製品情報

原材料

準備製品


クレソキシムメチル 生産企業

Global( 200)Suppliers
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143390-89-0(クレソキシムメチル)キーワード:


  • 143390-89-0
  • BAS 490F
  • Kresoxim-methyl 250mg [143390-89-0]
  • Methyl (E)-α-(methoxyimino)-2-(2-methylphenoxymethyl)phenylacetate
  • kresoxim-methyl (ISO) methyl (E)-2-methoxyimino-[2-(o-tolyloxymethyl)phenyl]acetate
  • Kresoxim-methyl, Methyl (E)-α-(methoxyimino)-2-(2-methylphenoxymethyl)phenylacetate
  • Cresoxime-methyl
  • Cygnus
  • Methyl (E)-2-methoxyimino-2-[2-(o-tolyloxymethyl) phenyl] acetate
  • Methyl (E)-a-(methoxyimino)-2-(2-methylphenoxymethyl)phenylacetate
  • alpha-(Methoxyimino)-2-[(2-methylphenoxy)methyl]benzeneacetic acid, (alpha,E)-Methyl ester
  • Kresoxim-methyl Standard
  • ALLEGRO
  • alpha-(Methoxyimino)-2-{(2-methylphenoxy)methyl}-benzeneacetic acid (E)-methyl ester
  • STROBY
  • MENTOR
  • KRESOXIM-METHYL
  • (E)-α-(methoxyimino)-2-((2-methylphenoxy)methyl)benzeneacetic acid methyl ester
  • kresoxim-mehtyl
  • methyl(E)-2-methoxyimino-(2-(o-tolyoxymethyl)phenyl)acetate
  • KRESOXIM-METHYL PESTANAL
  • KRESOXIM-METHYL INTERMEDIATES
  • Benzeneacetic acid, .alpha.-(methoxyimino)-2-(2-methylphenoxy)methyl-, methyl ester, (.alpha.E)-
  • kresoxim-methyl (bsi,iso)
  • BAS 490-02F
  • Candit
  • Discus (fungicide)
  • RIL-FA 200
  • Strob 1
  • Stroby WG
  • (E)-Methyl 2-(MethoxyiMino)-2-(2-((o-tolyloxy)Methyl)phenyl)acetate
  • クレソキシムメチル標準品
  • クレソキシムメチル
  • メチル=(E)-メトキシイミノ[2-(オルト-トリルオキシメチル)フェニル]アセタート (クレソキシルメチル)
  • メチル=(E)-メトキシイミノ[アルファ-(o-トリルオキシ)-o-トリル]アセタート (別名 クレソキシムメチル)
  • メチル=(E)-2-(メトキシイミノ)-2-{2-[(2-トリルオキシ)メチル]フェニル}アセタート
  • メチル=(E)-メトキシイミノ[Α-(O-トリルオキシ)-O-トリル]アセタート
  • クレソキシム‐メチル標準品
  • クレソキシム-メチル STANDARD
  • クレソキシム-メチル Standard, 100 µg/mL in Methanol
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