クロロチアジド 化学特性,用途語,生産方法
解説
サイアザイド(thiazide) 利尿剤の一つ。スルファニルベンゾサイアダイアジン系で、経口的投与によって有効に作用。
効能
血圧降下薬, 利尿薬, Na+-Cl-再吸収阻害薬
説明
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase
in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.
化学的特性
Off-White Solid
使用
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.
定義
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.
一般的な説明
Crystals; white powder.
空気と水の反応
Insoluble in water.
反応プロフィール
Alkaline aqueous solutions will decompose on standing or heating .
火災危険
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.
作用機序
The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.
安全性プロファイル
Moderately_toxic by
intraperitoneal and intravenous routes.
Mddly toxic by ingestion. Experimental
reproductive effects. Has been implicated in
aplastic anemia. When heated to
decomposition it emits very toxic fumes of
SOx NOx and Cl-.
クロロチアジド 上流と下流の製品情報
原材料
準備製品