클로로티아지드
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클로로티아지드 속성
- 녹는점
- 342-343°C
- 끓는 점
- 608.8±65.0 °C(Predicted)
- 밀도
- 1.7303 (rough estimate)
- 굴절률
- 1.6100 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(매우 소량, 가열)
- 산도 계수 (pKa)
- 6.85, 9.45(at 25℃)
- 색상
- 흰색에서 황백색까지
- 수용성
- 19.5&C에서 <0.1g/100mL
- Merck
- 14,2168
- BCS Class
- 4
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- LogP
- -0.240
- CAS 데이터베이스
- 58-94-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 42/43-20/21/22 | ||
| 안전지침서 | 36 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | DK9450000 | ||
| HS 번호 | 2935904000 | ||
| 유해 물질 데이터 | 58-94-6(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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클로로티아지드 C화학적 특성, 용도, 생산
개요
Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.화학적 성질
Off-White Solid용도
Chlorthiazide is a diuretic that causes the body to excrete excess fluid. This drug exhibits strong diuretic action during both acidosis and alkalosis. It is used for arterial hypertension, in edematous syndromes of various genesis, congestive effects in cardiovascular insufficiency, nephrosis and nephritis, and toxicosis. It is especially recommended for hypertonic illnesses. It lowers intraocular pressure in a number of cases.정의
ChEBI: Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent.일반 설명
Crystals; white powder.공기와 물의 반응
Insoluble in water.반응 프로필
Alkaline aqueous solutions will decompose on standing or heating .화재위험
Flash point data for Chlorothiazide are not available; however, Chlorothiazide is probably combustible.Mechanism of action
The mechanism of action of Chlorothiazide is an interference with the renal tubular mechanism of electrolyte reabsorption. The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism.Safety Profile
Moderately_toxic by intraperitoneal and intravenous routes. Mddly toxic by ingestion. Experimental reproductive effects. Has been implicated in aplastic anemia. When heated to decomposition it emits very toxic fumes of SOx NOx and Cl-.클로로티아지드 준비 용품 및 원자재
원자재
준비 용품
클로로티아지드 공급 업체
글로벌( 229)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Univar Solutions(China) Co., Ltd. | +8615902132654 |
ivy.zhuang@univarsolutions.com | China | 654 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 |
sale2@hbyalin.com | China | 1677 | 58 |
클로로티아지드 관련 검색:
해사 히드로클로로티아지드 설파닐아미드 이산화티오요소 금홍석 이산화탄소 이산화염소(기체) 테트라시클린 수화염화물 클로로디플루오르메탄
4-Amino-6-chlorobenzene-1,3-disulfonamide
3-Methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
6,7-Dichloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONYL DICHLORIDE
HYDROCHLOROTHIAZIDE-3,3-D2
Hydrochlorothiazide-13C,d2
Hydrochlorothiazide Impurity 4
1-CHLOROPHTHALAZINE
5-Chloroorthanilic acid