Y-26763 化学特性,用途語,生産方法
使用
Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.
生物活性
K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.
Y-26763 上流と下流の製品情報
原材料
準備製品