N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE 구조식 이미지
카스 번호:
127408-31-5
상품명:
N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
동의어(영문):
Y-26763;Y 26763,Y26763;N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Acetamide, N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxy-
CBNumber:
CB7841565
분자식:
C14H16N2O4
포뮬러 무게:
276.29
MOL 파일:
127408-31-5.mol

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE 속성

끓는 점
455.4±55.0 °C(Predicted)
밀도
1.36±0.1 g/cm3(Predicted)
저장 조건
Store at RT
용해도
Soluble to 100 mM in 1eq. NaOH
물리적 상태
가루
산도 계수 (pKa)
8.69±0.60(Predicted)

안전

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE C화학적 특성, 용도, 생산

용도

Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.

생물학적 활성

K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE 준비 용품 및 원자재

원자재

준비 용품


N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE 공급 업체

글로벌( 44)공급 업체
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Alchem Pharmtech,Inc.
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Aladdin Scientific
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
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BOC Sciences 1-631-485-4226; 16314854226
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EMMX Biotechnology LLC 888-539-0666
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Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
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Jiangsu aikang biomedical research and development co., LTD 025-66110311 13155353615
qzhang@aikonchem.com China 15527 58
Shanghai Anhua Biotechnology Co., Ltd. 021-61263375 18168859245
China 5958 58
Wuxi maimo topp biotechnology co., LTD 15861600115
lisa-li@mimotopes.cn China 5854 58

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