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プロピトカイン

プロピトカイン 化学構造式
721-50-6
CAS番号.
721-50-6
化学名:
プロピトカイン
别名:
アストラ1515;プリロカイン;N-(2-メチルフェニル)-2-(プロピルアミノ)プロパンアミド;プロピトカイン;アストラ1512;プロピトカイン (JAN)
英語化学名:
Prilocaine
英語别名:
l67;L 67;Priloca;Citanest;astra1512;astra1515;NSC 40027;Astra 1512;Astra 1515;PRILOCAINE
CBNumber:
CB8270843
化学式:
C13H20N2O
分子量:
220.31
MOL File:
721-50-6.mol

プロピトカイン 物理性質

融点 :
37-38°
沸点 :
bp0.1 159-162°
比重(密度) :
1.0117 (rough estimate)
屈折率 :
nD20 1.5298
貯蔵温度 :
2-8°C
溶解性:
Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
外見 :
neat
酸解離定数(Pka):
pKa 7.32 or 7.89 (Uncertain)
水溶解度 :
6.169g/L(25 ºC)
InChIKey:
MVFGUOIZUNYYSO-UHFFFAOYSA-N
CAS データベース:
721-50-6(CAS DataBase Reference)
NISTの化学物質情報:
Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)

安全性情報

HSコード  2924296000
有毒物質データの 721-50-6(Hazardous Substances Data)

プロピトカイン 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-6580 プリロカイン
Prilocaine
721-50-6 1g ¥6900 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01COBQJ-6580 プリロカイン
Prilocaine
721-50-6 5g ¥18000 2021-03-23 購入
Sigma-Aldrich Japan P2939000 European Pharmacopoeia (EP) Reference Standard
Prilocaine European Pharmacopoeia (EP) Reference Standard
721-50-6 ¥35200 2021-03-23 購入
Sigma-Aldrich Japan 1560990 プリロカイン United States Pharmacopeia (USP) Reference Standard
Prilocaine United States Pharmacopeia (USP) Reference Standard
721-50-6 200mg ¥74200 2021-03-23 購入
Sigma-Aldrich Japan P2939000 プリロカイン European Pharmacopoeia (EP) Reference Standard
Prilocaine European Pharmacopoeia (EP) Reference Standard
721-50-6 p2939000 ¥33600 2018-12-25 購入

プロピトカイン 化学特性,用途語,生産方法

用途

プリロカイン(英: Prilocaine)は、アミド型の局所麻酔薬の一つ。

効能

局所麻酔薬

化学的特性

White or almost white, crystalline powder.

使用

Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia.

使用

In terms of pharmacological parameters, prilocaine is comparable to lidocaine; however, because of a number of toxic manifestations, it is rarely used in medical practice. Citanest and xylonest are well-known synonyms for prilocaine.

定義

ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

一般的な説明

Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.

臨床応用

Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.

Chemical Synthesis

Prilocaine, 2-(propylamino)-o-propiontoluidine (2.2.14), is structurally related to the exact same group as ethidocaine, yet it differs structurally in that during synthesis, o-toluidine is used instead of 2,6-dimethylaniline, and instead of a butyric acid, a fragment of propionic acid, and a terminal propylethylamine group is replaced with a propylamine group. In order to synthesize prilocaine, o-toluidine is reacted with bromopropionyl bromide, and the resulting bromopropionyltoluidide (2.2.13) is then reacted with propylamine, which gives prilocaine [22,23].

プロピトカイン 上流と下流の製品情報

原材料

準備製品


プロピトカイン 生産企業

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721-50-6(プロピトカイン)キーワード:


  • 721-50-6
  • astra1512
  • o-Propionotoluidide, 2-(propylamino)- (6CI, 8CI)
  • Propanamide, N-(2-methylphenyl)-2-(propylamino)- (9CI)
  • N-(2-methylphenyl)-2-(propylamino)propionamide
  • Prilocaine (200 mg)
  • 2-(PropylaMino)-N-(o-tolyl)propanaMide
  • Prilocaine HCl (base)
  • Prilocaine N-(2-Methylphenyl)-2-propylamino-propanamide
  • (±)-2′-Methyl-2-(propylamino)propionanilide
  • PRILOCAINE USP API
  • 2-(propylamino)-o-propionotoluidid
  • 2-(Propylamino)-o-propionotoluidide
  • 2-Methyl-alpha-propylaminopropionanilide
  • alpha-n-Propyl-amino-2-methylpropionanilide
  • alpha-n-propylamino-2-methylpropionanilide
  • Astra 1512
  • Astra 1515
  • IN STOCK PRILOCAINE BASE CAS NO.721-50-6
  • PRILOCAINE BASE CAS NO.721-50-6
  • Prilocaine Cas number:(721-50-6)
  • Anesthesia Mepivacaine CAS NO. 721-50-6
  • N1-(2-methylphenyl)-N2-propylalaninamide
  • Prilocaine, >96%
  • PRILOCAINE
  • PRILOCAINE BASE
  • n-(2-methylphenyl)-2-propylamino-propanamide
  • astra1515
  • Citanest
  • L 67
  • l67
  • アストラ1515
  • プリロカイン
  • N-(2-メチルフェニル)-2-(プロピルアミノ)プロパンアミド
  • プロピトカイン
  • アストラ1512
  • プロピトカイン (JAN)
  • 局所麻酔薬
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