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Prilocaine

Local anesthetic drug Chemical Properties Uses Production method
Prilocaine
Prilocaine structure
CAS No.
721-50-6
Chemical Name:
Prilocaine
Synonyms
l67;L 67;Citanest;astra1515;astra1512;NSC 40027;PRILOCAINE;Astra 1512;Astra 1515;Propitocaine
CBNumber:
CB8270843
Molecular Formula:
C13H20N2O
Formula Weight:
220.31
MOL File:
721-50-6.mol

Prilocaine Properties

Melting point:
37-38°
Boiling point:
bp0.1 159-162°
Density 
1.0117 (rough estimate)
refractive index 
nD20 1.5298
solubility 
Slightly soluble in water, very soluble in acetone and in ethanol (96 per cent).
form 
neat
pka
pKa 7.32 or 7.89 (Uncertain)
InChIKey
MVFGUOIZUNYYSO-UHFFFAOYSA-N
CAS DataBase Reference
721-50-6(CAS DataBase Reference)
NIST Chemistry Reference
Propanamide, n-(2-methylphenyl)-2-(propylamino)-(721-50-6)

SAFETY

Hazardous Substances Data 721-50-6(Hazardous Substances Data)

Prilocaine price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P2939000 Prilocaine European Pharmacopoeia (EP) Reference Standard 721-50-6 p2939000 $179 2018-11-23 Buy
Sigma-Aldrich 1560990 Prilocaine United States Pharmacopeia (USP) Reference Standard 200mg $352.8 2018-11-13 Buy

Prilocaine Chemical Properties,Uses,Production

Local anesthetic drug

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline.
[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6~7min and the duration time of about 1.5~2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta.
[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring.
[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia.
[Usage and dosage] infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.
Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.
Epidural anesthesia: use10 to 30 mL of 1.5%~1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.
the structural formula of prilocaine
Figure 1 the structural formula of prilocaine
The above information is edited by the Chemicalbook of Dai Xiongfeng.

Chemical Properties

It is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless.

Uses

It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.

Production method

O-toluidine and α-bromo-propionyl bromide are condensed and further have reaction with propylamine obtain prilocaine.

Chemical Properties

White or almost white, crystalline powder.

Uses

Local anaesthetic.

Definition

ChEBI: An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.

General Description

Prilocaine hydrochloride is a water-soluble salt available asa solution for nerve block or infiltration in dental procedures.Prilocaine is used for intravenous regional anesthesiaas the risk of CNS toxicity is low because of the quick metabolism.Prilocaine prepared in the crystal form is used inEMLA for topical administration to decrease painful needlesticks in children. Prilocaine 4% solution should be protectedfrom light and the manufacturer recommends discardingif the solution turns pinkish or slightly darker than lightyellow. Solutions are available in various concentrations upto 4%, with or without epinephrine and with or withoutpreservatives.

Clinical Use

Prilocaine metabolism has beenstudied extensively in animal models, less is known aboutthe human metabolites or the human CYP enzymes involvedin their formation . The metabolism of prilocainein the liver yields o-toluidine, which is a possiblecarcinogen. Many aromatic amines, including o-toluidinehave been shown to be mutagenic, and metabolites of otoluidinehave been shown to form DNA adducts.Metabolites of o-toluidine are also believed to be responsiblefor the methemoglobinemia observed with prilocaineuse. To decrease the potential for methemoglobinemia, strictadherence to the maximum recommended dose should befollowed. Metabolism of prilocaine is extensive with lessthan 5% of a dose excreted unchanged in the urine.

Enzyme inhibitor

This powerful Na+ channel-blocking anesthetic (FWfree-base = 220.31 g/mol; CAS 721-50-6; HCl salt freely soluble in water) with properties resembling those of lidocaine, is an antagonist of b2-adrenergic receptors as well as an inhibitor of monoamine oxidase, Na+ channels, and Na+/K+- exchanging ATPase.

Prilocaine Preparation Products And Raw materials

Raw materials

Preparation Products


Prilocaine Suppliers

Global( 159)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Ruishun Trade Co.,LTD
17052563120
Mike@rsbiology.com CHINA 303 58
Anhui Dexinjia Biopharm Co., Ltd
86-531-82375818,82375892
86-531-82375893 alice@jndxj.com CHINA 129 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 294 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 495 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55

View Lastest Price from Prilocaine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Prilocaine Base
751-50-6
US $10.00 / KG 1KG 99.9% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-08-17 Prilocaine
721-50-6
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-23 Prilocaine Cas number:(721-50-6)
721-50-6
US $10.00-10.00 / G 10UG 99% 1000kg/month Hebei Chisure Biotechnology Co., Ltd.

721-50-6(Prilocaine)Related Search:


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