ChemicalBook
Chinese english Germany Korea

ベシル酸アトラクリウム

ベシル酸アトラクリウム 化学構造式
64228-81-5
CAS番号.
64228-81-5
化学名:
ベシル酸アトラクリウム
别名:
2,2'-[ペンタン-1,5-ジイルビス[オキシ(3-オキソ-3,1-プロパンジイル)]]ビス[1-[(3,4-ジメトキシフェニル)メチル]-1,2,3,4-テトラヒドロ-6,7-ジメトキシ-2-メチルイソキノリン-2-イウム]·2ベンゼンスルホン酸塩;アトラクリウムベシラート;ベシル酸アトラクリウム;アトラクリウムベシル酸塩 (異性体混合物)
英語化学名:
Atracurium besylate
英語别名:
51W89;BW-33A;Tracur;TRACRIUM;51W-89:Nimbex;Wellcome 33A74;Atracurium BesyL;tracurium Besylate;ATRACURIUM BESYLAT;ATRACURIUM BESILATE
CBNumber:
CB9379882
化学式:
C65H82N2O18S2
分子量:
1243.48
MOL File:
64228-81-5.mol

ベシル酸アトラクリウム 物理性質

融点 :
85-90°C
貯蔵温度 :
Inert atmosphere,2-8°C
溶解性:
H2O: ~27 mg/mL
外見 :
powder
色:
white
InChIKey:
YXSLJKQTIDHPOT-UHFFFAOYSA-N
CAS データベース:
64228-81-5(CAS DataBase Reference)

安全性情報

Sフレーズ  24/25
WGK Germany  3
HSコード  29334900

ベシル酸アトラクリウム 価格 もっと(11)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01LKTA7668 ベシル酸アトラクリウム
Atracurium Besylate
64228-81-5 50mg ¥15500 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01LKTA7668 ベシル酸アトラクリウム
Atracurium Besylate
64228-81-5 100mg ¥25100 2021-03-23 購入
Sigma-Aldrich Japan 1044800 United States Pharmacopeia (USP) Reference Standard
Atracurium besylate United States Pharmacopeia (USP) Reference Standard
64228-81-5 100mg ¥74200 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCA794500 ベシル酸アトラクリウム
Atracurium Besylate
64228-81-5 10mg ¥13800 2021-03-23 購入
富士フイルム和光純薬株式会社(wako) W01TRCA794500 ベシル酸アトラクリウム
Atracurium Besylate
64228-81-5 100mg ¥21300 2021-03-23 購入

ベシル酸アトラクリウム 化学特性,用途語,生産方法

効能

神経筋遮断薬

化学的特性

White to yellowish-white powder, slightly hygroscopic

Originator

Tracrium,Burroughs-Wellcome,US,1983

使用

A neuromuscular blocking agent

使用

antibacterial

定義

ChEBI: The bisbenzenesulfonate salt of atracurium.

Manufacturing Process

Acryloyl chloride (0.2 mol) in dry benzene (60 ml) was added over 0.5 hour with mechanical stirring to pentane-1,5-diol (0.1 mol), triethylamine (0.2 mol) and pyrogallol (0.1 g) in dry benzene (100 ml). Further dry benzene (ca 100 ml) was added followed by triethylamine (10 ml), and the mixture stirred at 50°C for 0.5 hour. The triethylamine hydrochloride was filtered off and the solvent removed in vacuum to leave a yellow oil which was distilled in the presence of a trace of p-methoxyphenol, excluding light, to give 1,5- pentamethylenediacrylate (12.9 g, 61%, BP 90° to 95°C/0.01 mm Hg).
A solution of tetrahydropapaverine (4.43 g) and 1,5-pentamethylene diacrylate (1.30 g) in dry benzene (15 ml) was stirred under reflux for 48 hours excluding light. The solvent was removed in vacuum and the residual pale red oil dissolved in chloroform (10 ml). Addition of ether (ca 400 ml), followed by saturated ethereal oxalic acid solution (ca 500 ml) gave a flocculent white precipitate, which was filtered off, washed with ether and dried. Crystallization (twice) from ethanol gave N,N'-4,10-dioxa-3,11- dioxotridecylene-1,13-bis-tetrahydropapaverine dioxalate as a white powder (3.5 g, 51%, MP 117° to 121°C).
The free base, N,N'-14,10-dioxa-3,11-dioxotridecylene-1,13-bistetrahydropapaverine, was obtained by basifying an aqueous solution of the dioxalate with sodium bicarbonate solution, followed by extraction with toluene and evaporation of the solvent, to give a colorless viscous oil. Scrupulously dried base (0.5 g) in spectroscopically pure acetonitrile (8 ml) was treated with methyl benzene sulfonate at room temperature for 22 hours. The filtered reaction mixture was added dropwise to mechanically stirred, filtered, dry ether (ca 450 ml). The flocculent white precipitate was filtered off, washed with dry ether, and dried in vacuum over P2O5 at 50°C to yield the product, an off-white powder melting at 85° to 90°C.
In practice it is usually used as dibenzenesulfonate.

brand name

Tracrium (Hospira).

Therapeutic Function

Neuromuscular blocker

生物学の機能

Atracurium besylate (Tracrium) is a benzylisoquinolinium compound like d-tubocurarine. Its actions are similar to those of d-tubocurarine, but its duration of action is shorter (45 minutes) because of spontaneous degradation of the molecule (Hofmann elimination). Because of this, atracurium is useful in patients with low or atypical plasma cholinesterase and in patients with renal or hepatic impairment.

一般的な説明

Atracurium besylate, 2-(2-carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate pentamethyleneester (Tracrium), is a nondepolarizing neuromuscular blockingagent that is approximately 2.5 times more potent thand-tubocurarine. Its duration of action (half-life, 0.33 hours)is much shorter than that of d-tubocurarine.

Biochem/physiol Actions

Nicotinic acetylcholine receptor antagonist.

臨床応用

Atracurium Besylate is metabolized rapidly and nonenzymatically to yield laudanosineand a smaller quaternary compound ,which do not have neuromuscular blocking activity. In vitroexperiments show that atracurium besylate breaks down atpH 7.4 and 37°C by a Hoffman elimination reaction.Atracurium besylate undergoes enzymatic decompositionof its ester function to yield an inactive quaternary alcoholand quaternary acid. AChE inhibitors such as neostigmine,edrophonium, and pyridostigmine antagonize paralysis byatracurium besylate.

Veterinary Drugs and Treatments

Atracurium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and also to facilitate endotracheal intubation. Atracurium can be used in patients with significant renal or hepatic disease.

ベシル酸アトラクリウム 上流と下流の製品情報

原材料

準備製品


ベシル酸アトラクリウム 生産企業

Global( 332)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Shanghai Minbiotech Co., Ltd.
+86 17315815539
sales@minbiotech.com CHINA 129 58
Wuhan Fortuna Chemical Co., Ltd
86-27-59207850
86-27-59524646 info@fortunachem.com CHINA 3073 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9165 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1011 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2940 58

64228-81-5(ベシル酸アトラクリウム)キーワード:


  • 64228-81-5
  • ATRACURIUM BESILATE
  • BW-33A
  • 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
  • 2,2’-[1,5-Pentanediylbis[oxy(3-oxcr3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
  • 51W-89:Nimbex
  • Atraeurium Besylate
  • Cisatracudum Besylate
  • BW-33A, Tracrium, 2,2μ-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
  • Isoquinolinium, 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate
  • Pentamethylen bis(3-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-2-isochinolyl)propionat)bis(benzolsulfonat)
  • Atracurium besylate,2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate, BW-33A, Tracrium
  • Atracurium Besylate (100 mg)
  • 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)meth
  • tracurium Besylate
  • 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-Isoquinolinium, benzenesulfonate (1:2)
  • AtracuriuM Besilete
  • (1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM
  • AtracuriuM besylate (TracriuM)
  • 51W89
  • Atracurium besylate, >=98%
  • Atracurium Besylate (mixture of isomers)
  • 2,2'-[1,5-PENTANEDIYLBIS[OXY(3-OXO-3,1-PROPANEDIYL)]]BIS[1-[3,4-DIMETHOXYPHENYL)METHYL]-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYLISOQUINOLINIUM]DIBENZENESULFONATE
  • TRACRIUM
  • ATRACURIUM BESILATE INJECTION
  • AtracuriumBesylate(DMF)
  • CisatracuriumBesilete
  • Atracurim besylate Bp
  • 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoic acid 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydr
  • 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium Benzenesulfonate
  • Atracurium Dibesylate
  • 2,2'-[ペンタン-1,5-ジイルビス[オキシ(3-オキソ-3,1-プロパンジイル)]]ビス[1-[(3,4-ジメトキシフェニル)メチル]-1,2,3,4-テトラヒドロ-6,7-ジメトキシ-2-メチルイソキノリン-2-イウム]·2ベンゼンスルホン酸塩
  • アトラクリウムベシラート
  • ベシル酸アトラクリウム
  • アトラクリウムベシル酸塩 (異性体混合物)
Copyright 2017 © ChemicalBook. All rights reserved