フレノシン 化学特性,用途語,生産方法
解説
N-2-hydroxytetracosanoylgalactocerebroside.C48H93NO9(828.27).フレノシン,セレブロンともいう.構成脂肪酸としてフレノシン酸(セレブロン酸)を有するβ-D-ガラクトセレブロシド.脳,神経組織,脊髄などに含まれる."針状または小板状結晶.融点212 ℃.[α]D+4.5°(10% ピリジン).熱ジオキサン,ブタノール,クロロホルム,ピリジンに可溶,エタノール,ベンゼンに不溶.種々の2-ヒドロキシ脂肪酸を含むものをフレノシン形,直鎖脂肪酸を含むものをケラシン形として区別されている.森北出版「化学辞典(第2版)
説明
Galactosylceramides are glycosphingolipids that contain galactose attached to a ceramide containing an N-acyl hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylceramides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in globoid cells in the brain of patients with Krabbe disease, a disorder characterized by a deficiency in galactosylcerebrosidase activity. This product is a mixture of isolated bovine hydroxy galactosylceramides. [Matreya, LLC. Catalog No. 1138]
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