ChemicalBook
Chinese English Japanese Germany Korea

Oxazolidinone

Oxazolidinone 구조식 이미지
카스 번호:
51667-26-6
상품명:
Oxazolidinone
동의어(영문):
Oxazolidinone;(R)-(-)-4-ISOPROPYL-3-PROPIMYL-2-OXAZOLIDINOE
CBNumber:
CB01028254
분자식:
C3H5NO2
포뮬러 무게:
87.0773
MOL 파일:
Mol file

Oxazolidinone 속성

안전

Oxazolidinone C화학적 특성, 용도, 생산

Pharmaceutical Applications

The oxazolidinones are a novel class of synthetic antimicrobial agents unrelated to any other antibacterial drug class. They were originally developed as monoamine oxidase inhibitors for treatment of depression, with subsequent recognition of their antimicrobial properties. The first members of the group to emerge exhibited potent activity against Gram-positive organisms, but were not developed for human use owing to toxicity in animal models. In the 1990s two less toxic oxazolidinones were developed: eperezolid, a piperazine derivative, and linezolid, a morpholine derivative. Linezolid exhibited the more favorable pharmacokinetic profile and was subsequently licensed for human use.
Numerous chemical analogs have been screened in a search for compounds with enhanced potency, a broader spectrum of activity or a more favorable side effect profile. Several promising candidates have been described, but linezolid remains the only oxazolidinone currently available.
These drugs are characterized by activity against Gram-positive organisms including methicillin-resistant Staphylococcus aureus, penicillin-resistant pneumococci and vancomycin-resistant enterococci. They are inactive against most Gram-negative species, although some investigational compounds are active against fastidious Gramnegative bacteria including Haemophilus influenzae. They have potentially useful activity against mycobacteria, including multiresistant isolates of Mycobacterium tuberculosis. Resistance among Grampositive organisms remains very uncommon (<0.5%) among clinical isolates.

Oxazolidinone 준비 용품 및 원자재

원자재

준비 용품


Oxazolidinone 공급 업체

글로벌( 4)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
XIANG DING CHEMICAL INTL CO.,LTD --
-- China 4375 63
Shanghai International Pharmaceutical Co., Ltd --
-- ronghua@wzpharm.com China 117 51
ecochem international chemical broker --
-- export@ecochem.dk Europe 6423 66
kemikalieimport --
-- Sales@kemikalieimport.dk Europe 6739 47

Copyright 2019 © ChemicalBook. All rights reserved