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nemorosone

nemorosone 구조식 이미지

카스 번호:: 351416-47-2

상품명:: nemorosone

동의어(영문):: nemorosone;(1R,5S,7S)-rel-5-benzoyl-4-hydroxy-6,6-dimethyl-1,3,7-tris(3-methyl-2-buten-1-yl)-bicyclo[3.3.1]non-3-ene-2,9-dione;Bicyclo[3.3.1]non-3-ene-2,9-dione, 1-benzoyl-4-hydroxy-8,8-dimethyl-3,5,7-tris(3-methyl-2-butenyl)-, (1R,5R,7S)- (9CI)

CBNumber:: CB01331583

분자식:: C33H42O4

포뮬러 무게:: 502.68

MOL 파일:: 351416-47-2.mol

속성

안전

용도

공급 업체 11

nemorosone 속성

끓는 점: 608.9±55.0 °C(Predicted)

밀도: 1.077±0.06 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);59.68(Max Conc. mM)

물리적 상태: 결정성 고체

산도 계수 (pKa): 4.50±1.00(Predicted)

색상: White to off-white

안전

nemorosone C화학적 특성, 용도, 생산

개요

Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties. Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC₅₀s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC₅₀ = >40 μM). It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nemorosone also inhibits growth of Capan-1, AsPC-1, and MIA-PaCa-2 pancreatic cancer cells (IC₅₀s = 4.5-5.0 μM following a 72-hour treatment) but not human dermal and foreskin fibroblasts (IC₅₀s = >35 μM). It induces apoptosis, abolishes the mitochondrial membrane potential, and increases cytosolic calcium concentration in pancreatic cancer cells in a dose-dependent manner. Nemorosone activates the caspase cascade in a dose-dependent manner and inhibits cell cycle progression, increasing the proportion of cells in the G₀/G₁ phase, in both neuroblastoma and pancreatic cancer cells. Nemorosone (50 mg/kg, i.p., per day) also reduces tumor growth in an MIA-PaCa-2 mouse xenograft model.

nemorosone 준비 용품 및 원자재

원자재

준비 용품

nemorosone 공급 업체

글로벌( 11)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32376	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	26070	58
Cayman Chemical Company	800-364-9897	sales@caymanchem.com	China	6838	58
Enzo Biochem Inc	Enzo Biochem Inc. 13797054060	Enzoname@qq.com	China	6174	58
Qingdao Everest Technology & Trade Co., Ltd.	13792478491		CHINA	0	58
Guangzhou Chuangze Biotechnology Co., Ltd.	18312220236		CHINA	0	58