Keep in dark place,Inert atmosphere,Room temperature
산도 계수 (pKa)
8.28±0.10(Predicted)
물리적 상태
액체
색상
무색
안전
위험 및 안전 성명
위험 및 사전주의 사항 (GHS)
HS 번호
2921490090
그림문자(GHS):
신호 어:
Warning
유해·위험 문구:
암호
유해·위험 문구
위험 등급
범주
신호 어
그림 문자
P- 코드
H302
삼키면 유해함
급성 독성 물질 - 경구
구분 4
경고
P264, P270, P301+P312, P330, P501
H315
피부에 자극을 일으킴
피부부식성 또는 자극성물질
구분 2
경고
P264, P280, P302+P352, P321,P332+P313, P362
H319
눈에 심한 자극을 일으킴
심한 눈 손상 또는 자극성 물질
구분 2A
경고
P264, P280, P305+P351+P338,P337+P313P
H335
호흡 자극성을 일으킬 수 있음
특정 표적장기 독성 - 1회 노출;호흡기계 자극
구분 3
경고
예방조치문구:
P261
분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338
눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
(R)-1-(2,4-Dichlorophenyl)ethanamine C화학적 특성, 용도, 생산
Synthesis
(5)-Mandelic acid (40.2 g, 264.5 mmol) was added to a solution of 3:2 isopropyl alcohol (/PrOH) and ethanol (EtOH) (500 mL) at room temperature, and the suspension was heated at 60 °C until a clear solution formed. Racemic 2,4-dichloro-a-methyl benzylamine (50 g, 264.5 mmol) was added to the hot solution, which was then cooled to 30 °C over 2 h and stirred at this temperature for 24 h. The colorless crystals were collected by filtration and washed with acetone (70 mL). The resulting salt was suspended in 3:2 /PrOH/EtOH (400 mL) at room temperature and the mixture was heated at 60 °C to give a clear solution. The solution was then cooled to room temperature and stirred for 24 hours. The colorless crystals were filtered off, and washed with acetone (40 mL) to give the desired salt. A portion of the salt (12.0 g) in dichloromethane (CH2C12) (100 mL) was added to aqueous 4 N sodium hydroxide solution (30 mL). The reaction mixture was stirred for 1 h at room temperature, and extracted with dichloromethane (2 χ 100 mL), dried with anhydrous sodium sulfate (Na2S04), filtered, and concentrated in vacuo to afford (R)-1-(2,4-Dichlorophenyl)ethanamine as a colorless liquid (7.5 g, 39.5 mmol, 40%).
