Unii-o0p4I5851i

Unii-o0p4I5851i C화학적 특성, 용도, 생산

Clinical Use

Lurasidone hydrochloride is an antipsychotic developed by the Japanese firm Dainippon Sumitomo and approved by the U.S. FDA for the treatment of schizophrenia. The compound exhibits significant antagonist effects at the D2, 5-HT2A, and 5-HT7 receptors which are linked to learning and cognition. In contrast to available antipsychotics, lurasidone lacks anticholinergic side effects, giving it an improved safety profile against existing treatments.139 The drug is manufactured under the trade name Latuda and possesses a linear molecular topology which can be subdivided into three regions: a piperazine benzothiazole, a [2.2.1]-bicycloheptane fused succinimide, and a trans-1,2 disubstituted cyclohexane.

Synthesis

The large scale preparation of lurasidone involves an interesting ring-opening alkylation reaction of a spirocyclic tetralkyl ammonium salt to produce the 1,2-trans-substituted cyclohexane subunit. The synthesis commenced with the bismesylation of commercially available diol 177, which proceeded in high yield to give disulfone 178. This bis-electrophile underwent dialkylation with commercially available piperazine 179 under basic conditions, giving rise to ammonium species 180, isolated in 80% yield as the mono-mesylate salt. This compound was immediately subjected to alkylative conditions in the presence of commercially available succinimide 181 to provide lurasidone in 94% yield from 180, and lurasidone hydrochloride (XVI) was achieved by subsequent salt formation procedure.

Unii-o0p4I5851i 준비 용품 및 원자재

원자재

준비 용품

Unii-o0p4I5851i 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Shandong Risen-Sun Pharmaceutical Co., Ltd	+86-15552509998 +86-15621883869	liutf@jewim.com.cn	China	251	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323967 +86-18015559028	sales1@artkmedchem.com	China	39009	58
Shenzhen SUNGENING Bio-Medical Co., Ltd.	0755-28967200 13631290199	wxf@sungening.com	China	9507	60
Conier Chem & Pharma Limited	13368167990	sales@conier.com	China	2809	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226 13028896684	sales@rrkchem.com	China	55954	58
Cato Research Chemicals Inc.	020-81215950 4000-868-328	customer@uwalab.com	United States	10413	58
Shaanxi Dideu Medichem Co. Ltd	029-61856359 18690052321	1027@dideu.com	China	10011	58