2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid C화학적 특성, 용도, 생산
효소 저해제
This AMPK activator (FW = 497.91 g/mol; CAS 331002-70-1),
systematically named 2-chloro-5-[[5-[[5- (4,5-dimethyl-2-nitrophenyl) -2-
furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid,
targets AMP-activated protein kinase (EC50 = 0.3 μM) by antagonizing its
built-in autoinhibition mechanism. PT1 dose-dependently activates
AMPK α1394, α1335, α2398, and even the heterotrimer α1β1γ1 form. Based on
the structure of PT1 docked to AMPK α1 subunit, it appears that PT1
interacts with Glu-96 and Lys-156 near the autoinhibitory domain, directly
relieving autoinhibition. In studies using L6 myotubes, the phosphorylation
of AMPK and its downstream substrate, acetyl-CoA carboxylase, were
dose-dependently and time-dependently increased by PT1 without any
change in cellular AMP:ATP concentration ratio.
2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid 준비 용품 및 원자재
원자재
준비 용품
2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoicacid 공급 업체
