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트라넥삼산

트라넥삼산
트라넥삼산 구조식 이미지
카스 번호:
1197-18-8
한글명:
트라넥삼산
동의어(한글):
트라넥삼산;트랜스-4-(아미노메틸)사이클로헥산카본산
상품명:
Tranexamic acid
동의어(영문):
AMCA;HAKU;dv-79;amcha;exacyl;tamcha;tranex;ugurol;LGB TA;amstat
CBNumber:
CB1117189
분자식:
C8H15NO2
포뮬러 무게:
157.21
MOL 파일:
1197-18-8.mol

트라넥삼산 속성

녹는점
>300 °C (lit.)
끓는 점
281.88°C (rough estimate)
밀도
1.0806 (rough estimate)
굴절률
1.4186 (estimate)
저장 조건
2-8°C
용해도
Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
산도 계수 (pKa)
pKa 4.3 (Uncertain);10.6 (Uncertain)
물리적 상태
Crystalline Powder
색상
White
수용성
1g/6ml
Merck
14,9569
BRN
2207452
InChIKey
GYDJEQRTZSCIOI-LJGSYFOKSA-N
CAS 데이터베이스
1197-18-8
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-37/39
WGK 독일 2
RTECS 번호 GU8400000
위험 등급 IRRITANT
HS 번호 29224999
독성 LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)
기존화학 물질 KE-01455
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

트라넥삼산 MSDS


Amstat

트라넥삼산 C화학적 특성, 용도, 생산

화학적 성질

White or almost white, crystalline powder.

Originator

Anvitoff,Knoll,W. Germany,1967

용도

Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

용도

Used as lysine analogue to characterize binding sites in plasminogen

용도

Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.

Manufacturing Process

In an autoclave, 2 grams of a mixture of cis- and trans-4- aminomethylcyclohexane-1-carboxylic acid, which is obtained by catalytic reduction of p-aminomethylbenzoic acid in the presence of platinum catalyst and contains 60% by weight of cis-isomer was reacted at 200°C, for 8 hours with 20 ml of ethyl alcohol in which 0.44 gram of sodium metal had been dissolved. After cooling, the reaction solution was concentrated under a reduced pressure to give a white residue. This residue was dissolved in 40 ml of water and passed through a column of a strongly acidic cation ion_x0002_exchanger resin (NH4+). The eluate was concentrated under reduced pressure to form a white mass. An adequate amount of acetone was added thereto and 1.95 grams of white powder was obtained. This powder was recrystallized from water-acetone to give 1.85 grams (yield, 92.5%) of white crystalline powder having a melting point of 380° to 390°C (decomposition). This product was identified as trans-4-aminomethylcyclohexane-1-carboxylic acid by means of infrared spectrum.

Therapeutic Function

Coagulant

일반 설명

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Mechanism of action

Tranexamic acid can also be viewed as a structural analog of lysine. It is presumed that it works by the same mechanism as aminocaproic acid; however, it is 6–10 times more active. It inhibits action of a plasmin and plasminogen inhibitor, and has a hemostatic effect.

Chemical Synthesis

Tranexamic acid, trans-4-(aminomethyl)cyclohexane carboxylic acid (24.4.5), is synthesized from 4-methylbenzonitrile. Oxidation of the methyl group gives the mononitrile of terephthalic acid 24.4.2. The cyano group in this compound is reduced by hydrogen using Raney nickel as a catalyst. The benzene ring of the resulting 4- aminomethylbenzoic acid (24.4.3) is reduced to a cyclohexane moiety by hydrogen and a platinum catalyst, which forms an isomeric mixture of 4-aminomethylcyclohexane carboxylic acids (24.4.4), and the desired trans-isomer 24.4.5 is isolated by crystallization of the mixture of its sodium salts.

트라넥삼산 준비 용품 및 원자재

원자재

준비 용품


트라넥삼산 공급 업체

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