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Amstat

Properties Coagulation and hemostasis drugs Indications Mechanism of action Pharmacokinetics Side effects
Amstat
Amstat structure
CAS No.
1197-18-8
Chemical Name:
Amstat
Synonyms
HAKU;AMCA;amcha;dv-79;amstat;LGB TA;exacyl;tamcha;tranex;ugurol
CBNumber:
CB1117189
Molecular Formula:
C8H15NO2
Formula Weight:
157.21
MOL File:
1197-18-8.mol

Amstat Properties

Melting point:
>300 °C(lit.)
Boiling point:
281.88°C (rough estimate)
Density 
1.0806 (rough estimate)
refractive index 
1.4186 (estimate)
storage temp. 
Store at 0°C
solubility 
Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent).
pka
pKa 4.3 (Uncertain);10.6 (Uncertain)
form 
Crystalline Powder
color 
White
Water Solubility 
1g/6ml
Merck 
14,9569
BRN 
2207452
InChIKey
GYDJEQRTZSCIOI-LJGSYFOKSA-N
CAS DataBase Reference
1197-18-8
EWG's Food Scores
1
FDA UNII
6T84R30KC1
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P280a-P304+P340-P405-P501a-P305+P351+P338-P261-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  2
RTECS  GU8400000
HazardClass  IRRITANT
HS Code  29224999
Toxicity LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)

Amstat price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 857653 trans-4-(Aminomethyl)cyclohexanecarboxylic acid 97% 1197-18-8 10g $45 2019-12-02 Buy
Sigma-Aldrich 1672745 Tranexamic acid United States Pharmacopeia (USP) Reference Standard 1197-18-8 200mg $352.8 2019-12-02 Buy
TCI Chemical A0236 trans-4-(Aminomethyl)cyclohexanecarboxylic Acid >98.0%(GC)(T) 1197-18-8 5g $13 2020-06-24 Buy
TCI Chemical A0236 trans-4-(Aminomethyl)cyclohexanecarboxylic Acid >98.0%(GC)(T) 1197-18-8 25g $24 2020-06-24 Buy
Alfa Aesar B21742 trans-4-(Aminomethyl)cyclohexanecarboxylic acid 97% 1197-18-8 10g $46 2020-06-24 Buy

Amstat Chemical Properties,Uses,Production

Properties

Amstat is an antifibrinolytic drug, commonly called Tranexamic acid. Tranexamic acid is a white crystalline powder. It is freely soluble in water and in glacial acetic acid and is very slightly soluble in ethanol and practically insoluble in ether.

Coagulation and hemostasis drugs

Tranexamic acid is a derivative of aminomethylbenzoic acid, and a kind of antifibrinolytic drugs to stop bleeding. The hemostasis mechanism of tranexamic acid is similar to aminocaproic acid and aminomethylbenzoic acid, but the effect is stronger. The strength is 7 to 10 times of aminocaproic acid, 2 times of aminomethylbenzoic acid, but toxicity is similar.
The chemical structure of tranexamic acid is similar to lysine, competitive inhibition of plasmin original in fibrin adsorption, to prevent their activation, protection fiber protein not to degrade by plasmin and dissolve, eventually achieve hemostasis. Applicable in the treatment of acute or chronic, localized or systemic primary fiber fibrinolytic hyperthyroidism caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hemorrhage of hypertrophy of the prostate, hemophilia, pulmonary tuberculosis hemoptysis, stomach bleeding, after operation of liver, lung, spleen and other viscera hemorrhage; also can be used in surgery when abnormal bleeding etc..
Clinical tranexamic acid has effect significantly to insect bites disease, dermatitis and eczema, simple purpura, chronic urticaria, artificial sex urticaria, toxic eruption and eruption. And also has a certain effect on erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles and alopecia areata. Treatment of hereditary angioedema effect is also good. In the treatment of Chloasma, general medicine is effective about 3 weeks, markedly effective 5 weeks, a course of 60 days. Given orally in doses of 0.25 ~ 0.5 g, a day 3 ~ 4 times. A few patients can nausea, fatigue, pruritus, abdominal discomfort, and diarrhea side effects after withdrawal symptoms disappear.

Indications

  1. Various bleedings caused by acute or chronic, localized or systemic primary hyperfibrinolysis; secondary hyperfibrinolytic state caused by disseminated intravascular coagulation. Generally do not use this product before heparinization.
  2. Trauma or surgical bleeding in tissue and organs with abundant plasminogen activators such as prostate, urethra, lung, brain, uterus, adrenal glands, and thyroid.
  3. An antagonist of tissue plasminogen activator (t-PA), streptokinase, and urokinase.
  4. Fibrinolytic hemorrhage caused by artificial abortion, early placental detachment, stillbirth and amniotic fluid embolism; and increased menorrhagia caused by pathological intrauterine fibrinolysis.
  5. Cerebral neuropathy mild bleeding, such as subarachnoid hemorrhage and intracranial aneurysm hemorrhage, the effect of Amstat in this condition is better than that of other anti-fibrinolytic agents. Special attention must be paid to the risk of cerebral edema or cerebral infarction.  For severe patients with surgical indications, this product can only be used as an adjuvant drug.
  6. For the treatment of hereditary angioneurotic edema, it can reduce the number and severity of episodes.
  7. Used in patients with hemophilia for their active hemorrhage in combination with others drug.
  8. Hemophilia patients with factor VIII or factor IX deficiency in their tooth extraction or oral surgery in case of operating bleeding.

Mechanism of action

Tranexamic acid is a synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure.

Pharmacokinetics

After a single oral administration of two 650 mg tablets of LYSTEDA, the peak plasma concentration (Cmax ) occurred at approximately 3 hours (Tmax ). The absolute bioavailability of LYSTEDA in women aged 18-49 is approximately 45%. Following multiple oral doses (two 650 mg tablets three times daily). administration of LYSTEDA for 5 days, the mean C max increased by approximately 19% and the mean area under the plasma concentration-time curve (AUC) remained unchanged, compared to a single oral dose administration (two 650 mg tablets). Plasma concentrations reached steady state at the 5th dose of LYSTEDA on Day 2.

Side effects

The table below contains some of the side-effects associated with tranexamic acid, although these occur only rarely.
Tranexamic acid side-effects
What can I do if I experience this?
Feeling or being sick
Stick to simple meals avoid rich and spicy food. If you are not already doing so, try taking the tablets after meals
Diarrhoea
Drink plenty of water to replace the lost fluids
Eyesight problems (such as problems with your colour vision)
Let your doctor know about this as soon as possible as your treatment will need to be reviewed

Chemical Properties

White or almost white, crystalline powder.

Uses

Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.

Uses

Used as lysine analogue to characterize binding sites in plasminogen

Uses

Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired.

Amstat Preparation Products And Raw materials

Raw materials

Preparation Products


Amstat Suppliers

Global( 464)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 304 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 157 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55

View Lastest Price from Amstat manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-08-13 Tranexamic acid
1197-18-8
US $150.00-120.00 / 公斤 1公斤 99.8% 100tons Hebei Runbin Biotechnology Co. LTD
2020-06-24 Tranexamic Acid
1197-18-8
US $114.00 / Kg/Drum 25KG 99% 50tons/month Hebei Yanxi Chemical Co., Ltd.
2020-06-23 LGB TA
1197-18-8
US $0.00 / Kg/Drum 1KG 99% 1000tons Hebei Mojin Biotechnology Co., Ltd

Amstat Spectrum


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