Mitoxantrone
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Mitoxantrone 속성
- 녹는점
- 170-1740C
- 끓는 점
- 554.47°C (rough estimate)
- 밀도
- 1.3049 (rough estimate)
- 굴절률
- 1.6500 (estimate)
- 저장 조건
- Keep in dark place,Sealed in dry,2-8°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨)
- 산도 계수 (pKa)
- pKa 5.99 (Uncertain);8.13 (Uncertain)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 진한 파란색에서 검정색까지
- CAS 데이터베이스
- 65271-80-9(CAS DataBase Reference)
- IARC
- 2B (Vol. 76) 2000
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 46-61-26/27/28 | ||
| 안전지침서 | 53-36/37/39-45-22 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | CB5748500 | ||
| HS 번호 | 2922.50.2500 |
Mitoxantrone C화학적 특성, 용도, 생산
화학적 성질
Dark Blue Crystalline Solid용도
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.Indications
Mitoxantrone (Novantrone) is a synthetic anthraquinone that is structurally and mechanistically related to the anthracyclines. It intercalates with DNA and produces single- strand DNA breakage. It is cross-resistant with doxorubicin in multidrug-resistant cells and in patients who have failed to respond to doxorubicin therapy.Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Mechanism of action
The mechanism of its action is not completely understood, although it is presumed, that mitoxantrone acts by binding with DNA, thus disturbing the twisting process of the chains. It is used intravenously for treating severe nonlymphatic leukemia, breast cancer, and so on. A synonym of this drug is novantrone.Mitoxantrone 준비 용품 및 원자재
원자재
준비 용품
Mitoxantrone 공급 업체
글로벌( 223)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 878 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29016 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 |
info@afinechem.com | CHINA | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9635 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 |
gksales1@gk-bio.com | China | 9338 | 58 |
Mitoxantrone 관련 검색:
1-히드록시에틸리덴-1,1-디포스포닌산 트리스(하이드록시메틸)아미노메탄 안트라센 안트라퀴논 하이드록시에틸 셀룰로스 이세티온산 소듐 염 1,5-디아미노클로로-4,8-디하이록시안트라퀴논 알리자린 알리자린 플루오린 블루 1,2,3,4-사염화-5,8-디하이드록시 안트라퀴논 C.I. 디스퍼스 블루 056 1,5-디아미노-2-브로모-4,8-디하이록시-9,10-안트라센디온
Hydroxyethyl starch
3-Diethylaminophenol
disodium 2,2-(5,8-dihydroxyanthraquinone-1,4-diyldiimino)bis(5-methylbenzenesulphonate)
4,5-diamino-1,8-dihydroxyanthraquinon
4,8-DIAMINO-1,5-DIHYDROXYANTHRAQUINONE-2,6-DISULFONIC ACID, DISODIUM SALT
2-Bromo-1,8-diamino-4,5-dihydroxyanthraquinone