눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
(1R,2S,5S)-6,6-DIMETHYL-3-AZA-BICYCLO[3.1.0]헥산-2-카르복실산메틸에스테르염산염 C화학적 특성, 용도, 생산
용도
(1S,2S,5R)-Methyl 6,6-diMethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate hydrochloride is an azabicyclohexane derivative used in the preparation of hepatitis C virus (HCV) NS3 serine protease inhibitor.
일반 설명
Boceprevir is a peptidomimetic protease inhibitor with four moieties, P1–P3 and a Cap, where P1 is a racemic β-aminoamide, P2 is a chiral dimethylcyclopropylproline analog, P3 is (S)-tert-leucine, and Cap is a tert-butylcarbamoyl group. The 3-azabicyclo[3.1.0]hexane structure of P2 adopts a constrained conformation, so that the gem-dimethyl group has a fixed angle with respect to the bicyclic ring structure. The incorporation of the 3-azabicyclo[3.1.0]hexane moiety results in a 1000-fold increase in NS3 protease binding over proline in a pentapeptide scaffold. When boceprevir binds to the NS3 protease, the P2 moiety interacts with four amino acid residues at the active site. The starting material for the P2 moiety is the HCl salt of the dimethylcyclopropylproline methyl ester 2. For medicinal chemistry studies, it was prepared by cyclopropanation of a Δ3-pyrroline derivative of pyroglutamic acid.
(1R,2S,5S)-6,6-DIMETHYL-3-AZA-BICYCLO[3.1.0]헥산-2-카르복실산메틸에스테르염산염 준비 용품 및 원자재
원자재
준비 용품
(1R,2S,5S)-6,6-DIMETHYL-3-AZA-BICYCLO[3.1.0]헥산-2-카르복실산메틸에스테르염산염 공급 업체