2-methyloxan-4-one

2-methyloxan-4-one 구조식 이미지
카스 번호:
1193-20-0
상품명:
2-methyloxan-4-one
동의어(영문):
2-methyltetrahydro-4H-pyran-4-one;2-Methyldihydro-2H-pyran-4(3H)-one;EOS-62013;2-Methyloxan-4-one;2-methyl-tetrahydropyran-4-one;tetrahydro-2-methyl-4H-Pyran-4-one;4H-Pyran-4-one, tetrahydro-2-methyl-;(RS)-2-methyl-tetrahydro-4H-pyran-4-one;2-methyl-tetrahydropyran-4-one ISO 9001:2015 REACH
CBNumber:
CB12501766
분자식:
C6H10O2
포뮬러 무게:
114.14
MOL 파일:
1193-20-0.mol

2-methyloxan-4-one 속성

끓는 점
168-169 °C
밀도
1.0229 g/cm3
물리적 상태
액체
색상
Clear, colourless
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
HS 번호 2932990090
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고 GHS hazard pictograms
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

2-methyloxan-4-one C화학적 특성, 용도, 생산

제조 방법

A solution of (2S)-2-methyltetrahydro-2H-pyran-4-ol (27.3 g, 235 mmol) in acetone (980 mL) was cooled in an ice bath and treated drop-wise with Jones reagent (2.5 M, 103 mL, 258 mmol). The reaction mixture was stirred for 10 minutes at 0 °C and then warmed to room temperature. After 30 minutes, the mixture was cooled to 0 °C. 2-Propanol (18 mL, 240 mmol) was added and stirred for 30 minutes. After the mixture had been concentrated in vacuo, the residue was partitioned between water and dichloromethane. The aqueous layer was extracted 3 times with dichloromethane, and the combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to provide the product 2-methyloxan-4-one.
2-methyl-tetrahydropyran-4-one

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 3494, 1994 DOI: 10.1021/jo00091a048

생물학적 활성

2-methyloxan-4-one has been shown to affect cell function and signal transduction in various cell types. It has been reported to inhibit the growth of cancer cells and induce apoptosis, or programmed cell death. It has also been shown to inhibit the production of inflammatory cytokines and reduce inflammation in animal models. However, the potential therapeutic and toxic effects of 2-methyloxan-4-one in humans are not well studied and require further investigation.

2-methyloxan-4-one 준비 용품 및 원자재

원자재

준비 용품


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