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UNC-0642

UNC-0642 구조식 이미지

카스 번호:: 1481677-78-4

상품명:: UNC-0642

동의어(영문):: CS-1714;UNC0642;UNC 0642;UNC-0642;UNC-0642;UNC0642;UNC 0642;UNC0642,inhibit,Inhibitor,Histone Methyltransferase;2-(4,4-difluoropiperidin-1-yl)-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine;2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine;4-Quinazolinamine, 2-(4,4-difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

CBNumber:: CB12668368

분자식:: C29H44F2N6O2

포뮬러 무게:: 546.7

MOL 파일:: 1481677-78-4.mol

속성

안전

용도

공급 업체 82

UNC-0642 속성

끓는 점: 679.2±65.0 °C(Predicted)

밀도: 1.23±0.1 g/cm3(Predicted)

저장 조건: 2-8°C

용해도: Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl

산도 계수 (pKa): 10.06±0.20(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고		P264, P270, P301+P312, P330, P501

예방조치문구:

P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

UNC-0642 C화학적 특성, 용도, 생산

용도

UNC 0642 is an in vivo chemical probe of the lysine methyltransferases G9a and GLP which maintains high in vitro and cellular potency, low cell toxicity, and selectivity.

Biochem/physiol Actions

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

UNC-0642 준비 용품 및 원자재

원자재

Methyl 2-aMino-5-Methoxy-4-(3-(pyrrolidin-1-yl)propoxy)benzoate Methyl 5-Methoxy-2-nitro-4-(3-(pyrrolidin-1-yl)propoxy)benzoate Methyl 4-(3-chloropropoxy)-5-Methoxy-2-nitrobenzoate 6-Methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline-2,4-diol Methyl 4-(3-chloropropoxy)-3-Methoxybenzoate 2,4-Dichloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 2-chloro-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine Methyl vanillate

준비 용품

UNC-0642 공급 업체

글로벌( 82)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+8618068519287	sales@xuanmingchem.com	China	822	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

UNC-0642 관련 검색:

UNC0321 (trifluoroacetate salt) UNC 1025 UNC0321 UNC3230 UNC2881 UNC2541 UNC 1079 UNC 0224 UNC3866 UNC0379 UNC 669 UNC2250 UNC-1215 UNC-926 Hydochloride UNC569 UNC0646 NUC-7738 UNC2025