Streptonigrin
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Streptonigrin 속성
- 녹는점
- 301-303℃
- 끓는 점
- 595.12°C (rough estimate)
- 밀도
- 1.4130 (rough estimate)
- 굴절률
- 1.6000 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- Chloroform:Methanol (1:1): 2 mg/ml
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 6.2-6.4 (1:1 aq dioxane)
- Merck
- 13,8907
- BRN
- 599390
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T+ | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 28 | ||
| 안전지침서 | 53-28-36/37/39-45 | ||
| 유엔번호(UN No.) | UN 3462 6.1/PG 1 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | TJ7350000 | ||
| F 고인화성물질 | 10-18 | ||
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II | ||
| 독성 | LD50 oral in mouse: 2330ug/kg |
Streptonigrin C화학적 특성, 용도, 생산
화학적 성질
Brown to red solid. Soluble in polar solvents and alkaline solutions; insoluble in most nonpolar solvents and acid solutions.용도
Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumour cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1).정의
ChEBI: Complex cytotoxic antibiotic obtained from Streptomyces flocculus or S. rufochronmogenus. It is used in advanced carcinoma and causes leukopenia.Purification Methods
Streptonigrin is purified by TLC on pH 7-buffered silica gel plates (made from a slurry of Silica Gel 60 and 400mL of 0.05M phosphate buffer pH 7.0) and eluted with 5% MeOH/CHCl3. Material from the extracted band recrystallises from Me2CO or dioxane as almost black plates or needles. It is soluble in pyridine, Me2NCHO, aqueous NaHCO3 (some dec), and slightly soluble in MeOH, EtOH, EtOAc and H2O. It has UV max 248, 375-380nm ( 38,400 and 17,400). [Weinreb et al. J Am Chem Soc 104 536 1982, Rao et al. J Am Chem Soc 85 2532 1963.] Itis antineoplastic and causes severe bone marrow depression [Wilson et al. Antibiot Chemother 11 147 1961].Streptonigrin 준비 용품 및 원자재
원자재
준비 용품
Streptonigrin 공급 업체
글로벌( 70)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
1015@dideu.com | China | 2263 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
| BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 |
2571773637@qq.com | China | 9821 | 58 |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 |
product@acmec-e.com | China | 33349 | 58 |
Streptonigrin 관련 검색:
이소아밀아민 2,4,6-콜리딘 2-아세틸피리딘
Jaceosidin
CHLOROPHYLL
3-(2-HYDROXYETHYL)PYRIDINE
1-(6-METHYL-PYRIDIN-2-YL)-ETHANONE
3-AMINO-6-PYRIDINEMETHANOL
6-Methyl-3-pyridineethanol
Streptonigrin
3-Amino-4-methylpyridine
3-METHYL-2-PYRIDINECARBOXALDEHYDE
6-METHYL-2-PYRIDINEMETHANOL
2,3,6-TRIMETHYLPYRIDINE
5-Methylpyridin-3-amine
2-FORMYL-4-PICOLINE
5-ACETYL-2-METHYLPYRIDINE
4-METHYL-PYRIDINE-2-CARBOXYLIC ACID