4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one
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4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one 속성
- 녹는점
- 155 °C(Solv: ethanol (64-17-5))
- 끓는 점
- 403.1±45.0 °C(Predicted)
- 밀도
- 1.412±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 4.50±1.00(Predicted)
안전
4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one C화학적 특성, 용도, 생산
Synthesis
4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one is obtaned by 2-Hydroxy-5-methoxy-acetophenone with sodium hydride in diethyl carbonate.2-Hydroxy-5-methoxy-acetophenone (1.50 g, 9.03 mmol) in diethyl carbonate (8.3 ml) was added dropwise into a suspension of sodium hydride (60% dispersion in mineral oil, 1.81 g, 45.2 mmol) in diethyl carbonate (8.3 ml) and heated under reflux at 100 ?C for 3 hours. The resultant mixture was left to cool to 0 ?C in an ice bath and quenched by dropwise addition of water until effervescence ceased. The aqueous layer was washed with diethyl ether (3 × 16 ml) then acidified using concentrated hydrochloric acid to pH 1. The precipitate was filtered and washed with water, followed by petroleum ether and left to dry overnight at 90 ?C to give the title compound as a colourless solid (902 mg, 52%): mp: 150 – 153 ?C (Lit.: 155 ?C); vmax/cm-1 3207bw (O-H), 1727s (C=O), 1655m (C=C), 1606s (aro. ring C=C); δH (300 MHz; DMSO-d6) 11.34 (1H, br. s., OH), 7.57 (1H, t, J 8.4, C(7)H), 6.95 (2H, d, J 8.4, C(6)H and C(8)H), 5.51 (1H, s, C(3)H), 3.90 (1H, s, OCH3); δC (75 MHz; DMSO-d6) 167.2 (Ar-C), 161.4 (Ar-C), 157.3 (Ar-C), 155.2 (Ar-C), 133.0 (Ar-CH), 109.2 (Ar-CH), 106.8 (Ar-CH), 105.0 (Ar-C), 90.8 (C(3)H), 56.5 (OCH3); m/z (-ES) 191 (100%, [M-H]-).4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one 준비 용품 및 원자재
원자재
준비 용품
4-Hydroxy-5-methoxy-2H-1-benzopyran-2-one 공급 업체
글로벌( 9)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Amadis Chemical Company Limited | 571-89925085 |
sales@amadischem.com | China | 131981 | 58 |
| BioPharmaMatrix,Inc. | 0510-86010668 |
sales@biopharmamatrix.com | China | 3365 | 55 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 |
sales@accelachem.com | China | 11728 | 58 |
| Shanghai Xiushi Biomedical Co., LTD | 15021598081,571034478; 15021598081 |
product001@xiushipharm.com | China | 4205 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Yingxin laboratory equipment Co., Ltd | 021-021-59178156 15300768757 |
359382369@qq.com | China | 10367 | 58 |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 |
1986399151@qq.com | China | 9849 | 58 |