Anti-Tau antibody, Mouse monoclonal C화학적 특성, 용도, 생산
용도
Anti-tau antibody, mouse monoclonal may be used in immunoblotting and immunoprecipitation.
일반 설명
Anti-tau antibody, mouse monoclonal (mouse IgG1 isotype) is derived from the tu53 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB /C mice. Tau, also known as microtubule-associated protein tau (MAPT), belongs to microtubule-associated proteins (MAP) family. It consists of six isoforms in the neurons of the adult human brain. MAPT gene is located on the human chromosome at 17q21.31.
Biochem/physiol Actions
Tau loses its microtubule-binding activity and aggregates into paired helical filaments (PHFs) during neurodegenerative disorders. It can undergo modifications such as hyperphosphorylation, nonenzymatic glycosylation and acetylation, which result in the generation of aberrant aggregates such as found in neurofibrillary tangles (NFTs) in Alzheimer′s disease. It is present abundantly in intraneuronal and glial fibrillar lesions formed during neurodegenerative disorders such as tauopathies and Alzheimer′s disease.
