Fas/FasL Antagonist, Kp7-6 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
An exocyclic cysteine-knot peptide that specifically antagonizes Fas/FasL-mediated cellular apoptotic signals (58% reduction of FasL-induced apoptosis in Jurkat cells at 1 mg/ml). Binds to FasL (Cat. Nos. PF033 and PF092) and Fas (CD95/APO-1) with comparable affinity (Kd = 11.2 & 13.2 μM, respectively), resulting in disabled receptor ensembles and altered signaling. Shown to prevent Con A (Cat. No. 234567)-induced liver injury in a murine hepatitis model in vivo. Does not bind to TNF-α or TNFR.
Biochem/physiol Actions
Product does not compete with ATP.
Fas/FasL Antagonist, Kp7-6 - Calbiochem 준비 용품 및 원자재
