InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 속성
안전
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem C화학적 특성, 용도, 생산
일반 설명
A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.
Biochem/physiol Actions
Cell permeable: yes
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 준비 용품 및 원자재
원자재
준비 용품
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 공급 업체
