InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem

InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 구조식 이미지
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InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem
동의어(영문):
InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem
CBNumber:
CB24817356
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 속성

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InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 M). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available.

Biochem/physiol Actions

Cell permeable: yes

InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 준비 용품 및 원자재

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InSolution Cdk1 Inhibitor IV, RO-3306 - Calbiochem 공급 업체

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공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

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