Phenethyl isothiocyanate
|
|
Phenethyl isothiocyanate 속성
- 녹는점
- 143~145℃
- 끓는 점
- 75 °C0.25 mm Hg
- 밀도
- 1.094 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.5888(lit.)
- 인화점
- >230 °F
- 저장 조건
- 2-8°C
- 용해도
- DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
- 물리적 상태
- 액체
- Specific Gravity
- 1.09
- 색상
- 무색~황색으로 투명함
- 냄새
- 프로필렌 글리콜 중 0.01%. 녹색 양 고추 냉이 구스베리 물냉이
- ?? ??
- 유황의
- 수용성
- 불용성
- 감도
- Moisture Sensitive
- JECFA Number
- 1563
- Merck
- 14,7226
- BRN
- 2084162
- InChIKey
- IZJDOKYDEWTZSO-UHFFFAOYSA-N
- LogP
- 3.47
- CAS 데이터베이스
- 2257-09-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-36/37/38-42-42/43 | ||
안전지침서 | 23-26-36-36/37 | ||
유엔번호(UN No.) | UN 2206 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | NX9115000 | ||
F 고인화성물질 | 10-23 | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | III | ||
HS 번호 | 29309090 | ||
독성 | LD50 in mice (mg/kg): 700 orally; 150 s.c.; 50 i.v. (Lichtenstein) |
Phenethyl isothiocyanate C화학적 특성, 용도, 생산
개요
Phenethyl isothiocyanate is a naturally occurring isothiocyanate in cruciferous vegetables. Phenethyl isothiocyanate is a chemopreventive agent. It inhibits cancer cell growth by arresting the cell cycle and inducing apoptosis in various human cancer cell models.화학적 성질
Phenethyl isothiocyanate has a strong green irritating odor.용도
Flavor ingredient; provides the hot or burning sensation in horseradish.Phenethyl isothiocyanate (PEITC),one of the major compounds from dietary cruciferousvegetables,has been found to have antitumor properties and therefore could generate special interest for the development of chemopreventive andor chemotherapeutic agent for human cancers.
제조 방법
Prepared by hydrolysis of gluconasturtiin, an abundant natural product present in cruciferous vegetables.정의
ChEBI: An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.일반 설명
Phenethyl isothiocyanate, an organic isothiocyanate, is a cruciferous vegetable ingredient present as a glucosinolate in cabbage, turnips, radishes, etc. It is a well-known chemopreventive agent reported to be effective against cancers affecting the lung, breast, pancreas, prostate and so on.Pharmacokinetics
Phenethyl isothiocyanate (PEITC) is one of the most extensively studied members of the isothiocyanate family, found in cruciferous vegetables, such as watercress. It is responsible for anti-cancer activities. In addition, it has shown to inhibit migration and invasion of many types of human cancer cells. PEITC selectively kills cancer cells, but not normal cells. It generates reactive oxygen species (ROS) to trigger signal transduction, leading to cell cycle arrest, autophagy, and/or apoptosis. However, the molecular mechanisms by which PEITC acts as a growth inhibitor and autophagy and/or apoptosis inducer in cancer cells have not been fully investigated. PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.Phenethyl Isothiocyanate has been used in trials studying the prevention and treatment of Leukemia, Lung Cancer, Tobacco Use Disorder, and Lymphoproliferative Disorders.
Anticancer Research
PEITC is a naturally occurring isothiocyanate, found mostly in cruciferous vegetablesincluding cauliflower, watercress, cabbage, Brussels sprouts, garden cress, broccoli,and bok choy. It shows chemopreventive and anticancer activity againstmelanoma, breast cancer, myeloma, human liver hepatoma, non-small cell lung cancer,cervical cancer, prostate cancer, and osteogenic sarcoma. It induces apoptosis in some drug resistance cell lines. Its mechanism of action is much diversified in variouscancer cells. It induces apoptosis in highly metastatic human non-small cell lungcancer, L9981 cells via caspase-3 activation, and cell cycle arrest in G2/M phase bymodulation of cyclin B1 expression while targeting MAPK/AP-1 pathway. In cervicalcancer cells, it increases the death receptor (DR4, DR5) expression, cleaves caspase-3, induces caspase-8, truncates BID, and downregulates ERK1/2 and MEKphosphorylation while maintaining the expression of JNK and phospho-p38MAPK. In human prostate cancer (DU 145) cell line, PEITC induces apoptosis byactivating caspase cascade pathway (Wang et al. 2012; Cheung and Kong 2010).Phenethyl isothiocyanate 준비 용품 및 원자재
원자재
준비 용품
Phenethyl isothiocyanate 공급 업체
글로벌( 205)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
JINING XINHE CHEMICAL CO., LTD | +8615318402391 |
sales@xinhepharma.com | China | 808 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29822 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13363 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
Phenethyl isothiocyanate 관련 검색:
페닐이소티오시아네이트 페녹시에틸 아이소부티레이트 아이소사이안산 디시오 옥사마이드 4-클로로페닐 이소시안산 이소티오시안산에틸에스테르 알릴 아이소사이오사이아네이트
Fluorescein isothiocyanate
BENZYL ISOTHIOCYANATE
3,4-DIMETHOXYPHENETHYL ISOTHIOCYANATE
2-(4-CHLOROPHENYL)ETHYL ISOTHIOCYANATE
(S)-(+)-1-PHENYLETHYL ISOTHIOCYANATE,(+)-1-PHENYLETHYL ISOTHIOCYANATE
(n)-1-phenylethyl isothiocyanate
(R)-(-)-1-PHENYLETHYL ISOTHIOCYANATE
2,4-dichloro-1-(2-isothiocyanatoethyl)benzene
2,5-DIMETHOXYPHENETHYL ISOTHIOCYANATE
2,2-DIPHENYLETHYL ISOTHIOCYANATE
4-METHYLPHENETHYL ISOTHIOCYANATE