4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘
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4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 속성
- 녹는점
- 145.0 to 149.0 °C
- 끓는 점
- 505.3±60.0 °C(Predicted)
- 밀도
- 1.49
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 클로로포름 (약간 용해됨), DMSO (약간 용해됨)
- 물리적 상태
- powder to crystal
- 산도 계수 (pKa)
- 1.73±0.30(Predicted)
- 색상
- White to Orange to Green
- InChI
- InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3
- InChIKey
- BTOJSYRZQZOMOK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 C화학적 특성, 용도, 생산
용도
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.Synthesis
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 준비 용품 및 원자재
원자재
준비 용품
4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 공급 업체
글로벌( 389)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shanghai Minbiotech Co., Ltd. | +8617315815539 |
sales@minbiotech.com | CHINA | 129 | 58 |
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 +86-18001856580 |
2415195517@qq.com | China | 43 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20293 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 811 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
4-클로로-7-토실-7H-피롤로[2,3-D]피리미딘 관련 검색:
트리플루오로티민 2-티오우라실
Tofacitinib Impurity T
N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
DEAZAPURINE
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine
2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE
4-Amino-7H-pyrrolo[2,3-d]pyrimidine
2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
2,4-DICHLORO-5H-PYRROLO[3,2-D]PYRIMIDINE
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine
Pyrrolo[2,3-d]pyrimidin-4-ol
N4-Benzoylcytosine
4-Aminopyrazolo[3,4-d]pyrimidine
5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine