4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 속성
- 녹는점
- 188-194 °C
- 끓는 점
- 289.2±50.0 °C(Predicted)
- 밀도
- 1.61±0.1 g/cm3(Predicted)
- 증기압
- 0Pa at 25℃
- 저장 조건
- Keep in dark place,Inert atmosphere,2-8°C
- 용해도
- DMSO, 에틸 아세테이트 및 메탄올에 용해됩니다.
- 물리적 상태
- 결정성 분말
- 산도 계수 (pKa)
- 11.42±0.20(Predicted)
- 색상
- 흰색에서 황갈색까지
- InChI
- InChI=1S/C6H4ClN3/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H,8,9,10)
- InChIKey
- BPTCCCTWWAUJRK-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C2C=CNC2=N1
- LogP
- 0.858 at 30℃
- CAS 데이터베이스
- 3680-69-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi,T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38-25-20/21/22 | ||
안전지침서 | 26-37-45-36 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UY9360000 | ||
TSCA | No | ||
위험 등급 | IRRITANT | ||
포장분류 | Ⅲ | ||
HS 번호 | 29335990 |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine C화학적 특성, 용도, 생산
화학적 성질
Lightbrown to brown crystalline powder용도
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is used in the manufacture of Tofacitinib citrate.Synthesis
The preparation process of pyrimidine includes the first α -alkylation reaction between diethyl malonate and allyl bromide, and the subsequent cyclization reaction with amidine to obtain a six-membered ring of bislactam. The chlorination of carbonyl with phosphorus oxychloride to obtain dichloro pyrimidine ring, followed by the oxidation of the terminal double bond with potassium osmate hydrate and sodium periodate to obtain the aldehyde group. The final reaction with ammonia water to produce SNAr/cyclization reaction, a five-step reaction, total yield of 45.8% to obtain 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 준비 용품 및 원자재
원자재
Pyrrolo[2,3-d]pyrimidin-4-ol
브로모아세트알데히드디에틸아세탈
탄산 칼륨
나트륨
포스포러스옥시클로라이드
아이오딘산나트륨
RANEY NICKEL
염화 암모늄
에틸 사이아노아세테이트
티오요소
준비 용품
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 공급 업체
글로벌( 924)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 |
shangli@bocchem.com | China | 138 | 58 |
Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 |
info@rochipharma.com | China | 431 | 58 |
changzhou huayang technology co., ltd | +8615250961469 |
2571773637@qq.com | China | 9827 | 58 |
Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 |
mw@qwpharmatech.com | China | 109 | 58 |
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 +86-18001856580 |
2415195517@qq.com | China | 43 | 58 |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 |
sales@aceschem.com | United States | 19639 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5987 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 |
sales@ichemie.com | China | 990 | 58 |
Anhui Lianchuang Biological Medicine Co.,Ltd | +8613706129682 |
tiffany@langyupharm.com | China | 86 | 58 |
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 관련 검색:
폴리비닐피로리돈 에피클로로하이드린 인돌 N-메틸-2-피롤리디논 티오황산 나트륨 펜타수화물 클로르디아제프 클로로아세트산 클로로디플루오르메탄
4-Chloropyrimidine
6-Chloropurine
1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE
Pyrimidine
DEAZAPURINE
N-((3R,4R)-1-benzyl-4-Methylpiperidin-3-yl)-N-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Methyl 4-chloropicolinate
4-Chloropyridinium chloride
2-Pyridinecarbonitrile,4-hydroxy-(9CI)