InSolution TAPI-1 - Calbiochem

InSolution TAPI-1 - Calbiochem 구조식 이미지
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InSolution TAPI-1 - Calbiochem
동의어(영문):
InSolution TAPI-1 - Calbiochem
CBNumber:
CB34817388
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0
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InSolution TAPI-1 - Calbiochem 속성

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InSolution TAPI-1 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).

Biochem/physiol Actions

Target IC50: 8.09 μM, 3.61 μM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors

InSolution TAPI-1 - Calbiochem 준비 용품 및 원자재

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준비 용품


InSolution TAPI-1 - Calbiochem 공급 업체

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