Imipenem + Cilastatin

Imipenem + Cilastatin C화학적 특성, 용도, 생산

Clinical Use

Imipenem is N-formimidoylthienamycin, the most successfulof a series of chemically stable derivatives of thienamycinin which the primary amino group is converted to a nonnucleophilicbasic function. Cilastatin is an inhibitor of DHPI.The combination (Primaxin) provides a chemically and enzymaticallystable form of thienamycin that has clinicallyuseful pharmacokinetic properties. The half-life of the drugis nonetheless short (t1/2 ～1 hour) because of renal tubularsecretion of imipenem. Imipenem retains the extraordinarybroad-spectrum antibacterial properties of thienamycin. Itsbactericidal activity results from the inhibition of cell wallsynthesis associated with bonding to PBPs 1b and 2.Imipenem is very stable to most β-lactamases. It is an inhibitorof β-lactamases from certain Gram-negative bacteriaresistant to other β-lactam antibiotics (e.g., P. aeruginosa, S.marcescens, and Enterobacter spp.).
Imipenem is indicated for the treatment of a wide variety ofbacterial infections of the skin and tissues, lower respiratorytract, bones and joints, and genitourinary tract, as well as ofsepticemia and endocarditis caused by β-lactamase–producingstrains of susceptible bacteria. These include aerobic Grampositiveorganisms such as S. aureus, Staphylococcus epidermidis,enterococci, and viridans streptococci; aerobic Gramnegativebacteria such as E. coli, Klebsiella, Serratia,Providencia, Haemophilus, Citrobacter, and indole-positiveProteus spp., Morganella morganii, Acinetobacter andEnterobacter spp., and P. aeruginosa and anaerobes such as B.fragilis and Clostridium, Peptococcus, Peptidostreptococcus,Eubacterium, and Fusobacterium spp. Some Pseudomonasspp. are resistant, such as P. maltophilia and P. cepacia, as aresome methicillin-resistant staphylococci. Imipenem is effectiveagainst non–β-lactamase-producing strains of these andadditional bacterial species, but other less expensive andequally effective antibiotics are preferred for the treatment ofinfections caused by these organisms.
The imipenem–cilastatin combination is marketed as asterile powder intended for the preparation of solutions for intravenousinfusion. Such solutions are stable for 4 hours at25°C and up to 24 hours when refrigerated. The concomitantadministration of imipenem and an aminoglycoside antibioticresults in synergistic antibacterial activity in vivo. The twotypes of antibiotics are, however, chemically incompatibleand should never be combined in the same intravenous bottle.

Imipenem + Cilastatin 준비 용품 및 원자재

원자재

준비 용품

Imipenem + Cilastatin 공급 업체

공급자	전화	이메일	국가	제품 수	이점
M/s Kaanav Pharma	--		India	2	58
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd	--	sales@yickvic.com	China	6214	58
A.T.CHEMICAL	--	Jeffreyxu@atchem.net	China	6594	51

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