Cilastatin
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Cilastatin 속성
- 녹는점
- 156-158°C
- 끓는 점
- 655.5±55.0 °C(Predicted)
- 밀도
- 1.275±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨, 초음파처리)
- 산도 계수 (pKa)
- 2.09±0.10(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 밝은 갈색까지
- CAS 데이터베이스
- 82009-34-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Cilastatin C화학적 특성, 용도, 생산
개요
Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin . In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection. Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life. Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.화학적 성질
White to Light-Yellow Crystalline Powder용도
Cilastatin is used for treating diseases caused by polyresistant Gram-negative microorganisms and serious complex infections, including infection of S. aureus. Because of its strong activity against anaerobic bacteria, cilastatin is effective in monotherapy of intraabdominal infections. It is used for infectious diseases of the lower respiratory tract, urinary tract, gynecological infections, bacterial septicemia, and infections of the bones, skin, and so on.Cilastatin 준비 용품 및 원자재
원자재
N,N'-DIOCTADECYLOXACARBOCYANINE P-TOLUENESULFONATE, 99
Amine compound
1,5-디브로모펜탄
에틸 헵타노에이트
P-톨루엔설폰 산
1-사이클로프로필-6,7-디플루오로-1,4-디하이드로-8-메톡시-4-옥소-3-퀴놀린카르복실산에틸에스테르
수산화칼륨
디에톡시아세트에틸에스테르
(S)-2,2-디메틸사이클로프로판카복사미드
아세틸불화물
숙신산이미드
1,3-Dithiane-2-carboxylic acid
파라-톨루엔설폰일 염화물
L-(-)-시스틴
1,3-프로판디티올
시클로프로판카복산에틸에스테르
2,2-Dimethylcyclopropylcyanide
사이안화 칼륨
퀴닌
Activ Ester
준비 용품
Cilastatin 공급 업체
글로벌( 245)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Cilastatin 관련 검색:
글리신 다이메틸 설폭사이드 다이메틸폴리실록산 베타인 N,N-디메틸아세트아미드 다이메틸-p-페닐엔디아민 N,N-다이메틸폼아마이드 메틸 술폰 디메티콘
CHLOROPHOSPHONAZO III
Betahistine
ALTRENOGEST
Lithium diisopropylamide
ULINASTATIN
Cilastatin Sodium Impurity E(EP)
Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate
1-Bromo-5-chloropentane
Ethyl 7-chloro-2-oxoheptanoate