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V-9-M cholecystokinin nonapeptide

V-9-M cholecystokinin nonapeptide 구조식 이미지

카스 번호:: 99291-20-0

상품명:: V-9-M cholecystokinin nonapeptide

동의어(영문):: Cholecystokinin Precursor (24-32) (rat) H-Val-Pro-Val-Glu-Ala-Val-Asp-Pro-Met-OH;Smeglutide;Semaglutide（Recombinant）;Cholecystokinin Precursor;V-9-M cholecystokinin nonapeptide;L-Valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-L-methionine;L-Methionine,L-valyl-L-prolyl-L-valyl-L-a-glutamyl-L-alanyl-L-valyl-L-a-aspartyl-L-prolyl-;L-Methionine, L-valyl-L-prolyl-L-valyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-prolyl-;(4S)-4-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[(2S)-2-[[(1S)-1-carboxy-3-methylsulfanylpropyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

CBNumber:: CB41331642

분자식:: C42H69N9O14S

포뮬러 무게:: 956.11

MOL 파일:: 99291-20-0.mol

속성

안전

용도

공급 업체 92

V-9-M cholecystokinin nonapeptide 속성

끓는 점: 1350.7±65.0 °C(Predicted)

밀도: 1.306±0.06 g/cm3(Predicted)

산도 계수 (pKa): 3.51±0.10(Predicted)

InChIKey: AIKMAJWJXJPJNB-HNRKYVDVNA-N

안전

V-9-M cholecystokinin nonapeptide C화학적 특성, 용도, 생산

개요

V-9-M Cholecystokinin nonapeptide is a glucagon-like peptide receptor agonist, namely GLP-1 receptor agonist. Human GLP-1 is a peptide hormone secreted by intestinal L cells. Cholecystokinin Precursor (24-32), rat has apparent sedative actions and prevents experimental amnesisa in rats.

용도

V-9-M cholecystokinin nonapeptide belongs to the glucagon-like peptide-1 receptor agonist (GLP-1 receptor agonist) class of hypoglycemic drugs, which increase insulin secretion in a glucose-dependent manner and inhibit glucagon secretion , and can promote gastric emptying, centrally suppress appetite, reduce food intake, and then reduce glucose absorption to achieve the effect of lowering blood sugar.

Mechanism of action

V-9-M cholecystokinin nonapeptide's mechanism of action is to act on islet beta cells, promote the synthesis and secretion of insulin, stimulate the proliferation and differentiation of islet beta cells, inhibit the apoptosis of islet beta cells, increase the number of islet beta cells, and protect islet function. It can also act on islet alpha cells, inhibit the release of glucagon, and reduce the release of hepatic glucose.

저장

Store at low temperatures to avoid moisture:
Powder: -20°C, 3 years.
Solvents: -80°C, 2 years.

참고 문헌

1. Takashima A, Itoh S. Neuropharmacological properties of V-9-M, a putative neuropeptide derived from procholecystokinin, in the rat. Can J Physiol Pharmacol. 1989 Mar;67(3):223-7. DOI: 10.1016/0301-0082(90)90035-F
2. Cholecytokinin (CCK) gene-related peptides: distribution and characterization of immunoreactive pro-CCK and an amino-terminal pro-CCK fragment in rat brain. DOI: 10.1016/0006-8993(85)90813-3
3. Cao G, Beinfeld MC. Calcium-dependent pro-cholecystokinin V-9-M immunoreactive peptide release from rat brain slices and CCK-secreting rat medullary thyroid carcinoma cells in culture. Peptides. 1992 Nov-Dec;13(6):1087-90. DOI: 10.1016/0196-9781(92)90011-Q

V-9-M cholecystokinin nonapeptide 준비 용품 및 원자재

원자재

준비 용품

V-9-M cholecystokinin nonapeptide 공급 업체

글로벌( 92)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Maintain Biotech Co., Ltd.	+86-75589664337 +86-15112661142	cami@maintain-bio.com	China	66	58
Hantai Biomedical Group Co. LTD	+8618819265912	id002@cnhantide.com	China	37	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Dorne Chemical Technology co. LTD	+86-13583358881 +86-18560316533	Ethan@dornechem.com	China	294	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-19164747840 +86-13119157289	13119157289@163.com	China	2971	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3000	58
Wuhan Haorong Biotechnology Co.,ltd	+8618565342920	sales@chembj.net	China	269	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58

V-9-M cholecystokinin nonapeptide 관련 검색:

H-GLY-TYR-PRO-GLY-LYS-PHE-OH NEUROPEPTIDE W-30 (RAT) Atrial Natriuretic Factor (3-28) (rat) ANGIOTENSINOGEN (1-14) (RAT) ATRIAL NATRIURETIC PEPTIDE (126-150) (RAT) BNP-32 (RAT) CORTISTATIN-14 GHRELIN (RAT) COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) ATRIOPEPTIN I (RAT) Cholecystokinin