kobusine

kobusine C화학적 특성, 용도, 생산

개요

Obtained by Suginome and Shimanouti from the precipitation liquors of crude jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I: 0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]²²_D + 40.68° (H20); hydrochloride (1.5 H20) has m.p. 300°C (dec.);[α]²¹_Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.) although a value of 220°C has also been recorded for this salt; platinichloride, m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C (dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p. 183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.

참고 문헌

Suginome, Shimanouti., Annalen, 545, 220 (1940)
Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
Natsume., ibid, 7,539 (1959)

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TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

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