Anti-stromal interaction molecule 2

Anti-stromal interaction molecule 2 구조식 이미지
카스 번호:
상품명:
Anti-stromal interaction molecule 2
동의어(영문):
Anti-stromal interaction molecule 2;Anti-STIM2 antibody produced in rabbit;Anti-STIM2 (ab2) antibody produced in rabbit;Anti-STIM2 (ab1) antibody produced in rabbit
CBNumber:
CB42102076
분자식:
포뮬러 무게:
0
MOL 파일:
Mol file

Anti-stromal interaction molecule 2 속성

저장 조건
-20°C
물리적 상태
완충 수용액

안전

Anti-stromal interaction molecule 2 C화학적 특성, 용도, 생산

용도

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

일반 설명

STIM (stromal interaction molecule) proteins are conserved single-pass transmembrane protein. The three STIM proteins, STIM1, STIM2 and D-Stim, are ubiquitously expressed proteins composed of a single SAM (sterile α-motif) domain and an unpaired EF hand within the highly conserved extracellular region and coiled-coil domains that are conserved in structure and position within the cytoplasmic region. Significant divergence between these proteins was found only at the extreme C-termini. STIM proteins are modified by phosphorylation and N-linked glycosylation.

Biochem/physiol Actions

STIM (stromal interaction molecule) required for the regulation of store-operated Ca2+ influx. Store-operated calcium entry is mediated by Ca2+ release-activated Ca2+ (CRAC) channels, following Ca2+ depletion from the endoplasmic reticulum (ER) stores. This process is crucial for gene transcription, proliferation and cytokine release. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ entry. STIM2 co-localizes with STIM1 in punctae upon store depletion, and coprecipitates with STIM1 from cell lysates, suggesting that they may play a coordinated role in controlling Ca2+ entry.

Anti-stromal interaction molecule 2 준비 용품 및 원자재

원자재

준비 용품


Anti-stromal interaction molecule 2 공급 업체

글로벌( 3)공급 업체
공급자 전화 이메일 국가 제품 수 이점
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

Copyright 2019 © ChemicalBook. All rights reserved