ChemicalBook >제품 카탈로그 >5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one 구조식 이미지

카스 번호:: 877636-42-5

상품명:: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one

동의어(영문):: ML221;CS-2842;ML 221;ML-221;ML221 >=98% (HPLC);ML221; ML 221; ML-221;ML-221,inhibit,ML 221,Inhibitor,ML221;4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate;5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one;4H-Pyran-4-one, 5-[(4-nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-

CBNumber:: CB42750703

분자식:: C17H11N3O6S

포뮬러 무게:: 385.35

MOL 파일:: 877636-42-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 61

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one 속성

끓는 점: 624.1±55.0 °C(Predicted)

밀도: 1.54±0.1 g/cm3(Predicted)

저장 조건: Sealed in dry,2-8°C

용해도: DMSO: 용해성5mg/mL, 투명(가온)

산도 계수 (pKa): 0.30±0.33(Predicted)

물리적 상태: 가루

색상: 흰색에서 베이지색

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one C화학적 특성, 용도, 생산

개요

ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC₅₀ = 4.8 μM). It is selective for APJ over the angiotensin II type 1 (AT₁) receptor (IC₅₀ = >78 μM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC₅₀s = 0.7 and 1.75 μM, respectively). It inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells when used at concentrations ranging from 5 to 15 μM. In vivo, ML-221 (150 μg/kg) reduces tumor growth in a Mz-ChA-1 mouse xenograft model. Intrathecal injection of ML-221 (10 μg per animal) reduces mechanical allodynia and heat hyperalgesia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. ML-221 also inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy.

용도

ML 221 is a functional antagonist of the apelin (APJ) receptor which is shown to treat or mediate the homeostasis of the cardiovascular system.

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one 준비 용품 및 원자재

원자재

준비 용품

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one 공급 업체

글로벌( 61)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4121	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one 관련 검색:

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