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피피트린-α,p-니트로,사이클릭

피피트린-α,p-니트로,사이클릭 구조식 이미지

카스 번호:: 60477-38-5

한글명:: 피피트린-α,p-니트로,사이클릭

동의어(한글):: 피피트린-α,p-니트로,사이클릭

상품명:: Pifithrin-α, p-nitro, cyclic

동의어(영문):: PFN-α;p-Nitro-CyclicPifithrin-α;p-Nitro-Cyclic Pifithrin-a;Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic Pifithrin-α;Cyclic pifithrin-α-p-nitro;Pifithrin-α, p-nitro, cyclic;Pifithrin-alpha, p-Nitro, Cyclic;p-nitro Cyclic Pifithrin-.alpha.;Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem

CBNumber:: CB43136760

분자식:: C15H13N3O2S

포뮬러 무게:: 299.35

MOL 파일:: 60477-38-5.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 31

피피트린-α,p-니트로,사이클릭 속성

녹는점: 233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))

밀도: 1.53±0.1 g/cm3(Predicted)

저장 조건: -20C

용해도: ≤1mg/ml in dimethyl formamide

물리적 상태: 노란색 고체

산도 계수 (pKa): 6.14±0.20(Predicted)

색상: Light yellow to yellow

안전

피피트린-α,p-니트로,사이클릭 C화학적 특성, 용도, 생산

용도

p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.

일반 설명

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED₅₀ = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t_1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

Biochem/physiol Actions

Cell permeable: yes

피피트린-α,p-니트로,사이클릭 준비 용품 및 원자재

원자재

준비 용품

피피트린-α,p-니트로,사이클릭 공급 업체

글로벌( 31)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
SHANGHAI KEAN TECHNOLOGY CO., LTD.	+8613817748580	cooperation@kean-chem.com	China	40068	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2945	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3250	58