피피트린-α,p-니트로,사이클릭

피피트린-α,p-니트로,사이클릭
피피트린-α,p-니트로,사이클릭 구조식 이미지
카스 번호:
60477-38-5
한글명:
피피트린-α,p-니트로,사이클릭
동의어(한글):
피피트린-α,p-니트로,사이클릭
상품명:
Pifithrin-α, p-nitro, cyclic
동의어(영문):
PFN-α;p-Nitro-CyclicPifithrin-α;p-Nitro-Cyclic Pifithrin-a;Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic Pifithrin-α;Cyclic pifithrin-α-p-nitro;Pifithrin-α, p-nitro, cyclic;Pifithrin-alpha, p-Nitro, Cyclic;p-nitro Cyclic Pifithrin-.alpha.;Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
CBNumber:
CB43136760
분자식:
C15H13N3O2S
포뮬러 무게:
299.35
MOL 파일:
60477-38-5.mol
MSDS 파일:
SDS

피피트린-α,p-니트로,사이클릭 속성

녹는점
233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
밀도
1.53±0.1 g/cm3(Predicted)
저장 조건
-20C
용해도
≤1mg/ml in dimethyl formamide
물리적 상태
노란색 고체
산도 계수 (pKa)
6.14±0.20(Predicted)
색상
Light yellow to yellow

안전

피피트린-α,p-니트로,사이클릭 C화학적 특성, 용도, 생산

용도

p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.

일반 설명

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

Biochem/physiol Actions

Cell permeable: yes

피피트린-α,p-니트로,사이클릭 준비 용품 및 원자재

원자재

준비 용품


피피트린-α,p-니트로,사이클릭 공급 업체

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