아파민
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아파민 속성
- 끓는 점
- 847.17°C (rough estimate)
- 밀도
- 1.63
- 굴절률
- 1.5530 (estimate)
- 저장 조건
- -20°C
- 용해도
- 0.05 M 아세트산: 5 mg/mL, 투명, 무색 ~ 희미한 노란색
- 물리적 상태
- 어두운 황갈색을 띤 흰색 고체
- 색상
- White to off-white
- 수용성
- Soluble to 1 mg/ml in water
- Merck
- 13,732
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
안전지침서 | 22-24/25 | ||
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유엔번호(UN No.) | 2811 | ||
WGK 독일 | 3 | ||
RTECS 번호 | CD6899900 | ||
F 고인화성물질 | 3-10 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
독성 | LD50 i.v. in mice: 4 mg/kg (Habermann, Reiz); LD50 intracerebroventricularly in mice: 12 ng/animal (Labbé-Jullié) |
그림문자(GHS): | |||||||||||||||
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신호 어: | Danger | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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아파민 C화학적 특성, 용도, 생산
화학적 성질
Small, highly potent, highly basic polypeptide.용도
Apamin has been used:- As a selective inhibitor of small conductance (SKCa) channels in HEK cells.
- To inhibit endothelium-derived relaxing factor (EDHF) mediated responses.
- To block small-conductance Ca2-activated K current (ISK) in electrophysiological studies in hyperstriatum ventrale, pars caudalis (HVc) neurons.
정의
Occurs in the venom of the honey bee, Apis mellifera; molecular weight of 2027.38.일반 설명
Apamin is a bee venom component and is strongly basic in nature. It has 18 amino acid residues and two disulphide bonds.위험도
Central nervous system poison able to cross the blood–brain barrier; neurotoxic; poison.Safety Profile
Poison by intravenous, parenteral,intracerebral, and intraperitoneal routes. When heated todecomposition it emits toxic fumes of SOx and NOx.효소 저해제
This bee venom octadecapeptide toxin (FW = 2027.34 g/mol; CAS 24345- 16-2; NCBI Reference Sequence: NP_001011612.1) potently blocks the small-conductance Ca 2+ -activated potassium ion (or SK) channels hSK1 as well as rSK2, with IC50 values of 3.3 nM and 83 pM. It shows greater effectiveness at the SK2 channel (IC50 = 0.06-0.4 nM) than SK1 (IC50 = 1- 12 nM). SK3 (IC50 = 1-13 nM), and SK4 (IC50 = 1 μM) channels, and is active against channels within neurons, vascular endothelium, bladder smooth muscle, and certain cancers. Apamin does not inhibit human cardiac Na + current, L-type Ca 2+ current or other major K+ currents. Structurally, apamin forms a stable structure, consisting of a C-terminal a- helix and two reverse turns, that is stabilized by two disulfide bonds connecting Cys-1 to Cys-11 and Cys-3 to Cys-15. A minor constituent of venom of the bee (Apis mellifera), apamin amounts to only 2-3% (w/w) of its dry venom. The smallest known neurotoxic polypeptide, apamin is derived by proteolytic processing of the 48-residue pre-pro-protein. The precursors of the bee venom constituents apamin and MCD peptide are encoded by two genes in tandem which share the same 3'-exon.아파민 준비 용품 및 원자재
원자재
준비 용품
아파민 공급 업체
글로벌( 153)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 |
admin@nexconn.com | China | 10311 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 |
contact@fuxinpharm.com | China | 10297 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 |
dominicguo@gk-bio.com | CHINA | 9427 | 58 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
Hangzhou Go Top Peptide Biotech | 0571-88211921 |
sales1@gotopbio.com | CHINA | 2609 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
아파민 관련 검색:
Glibenclamide
Nicorandil
CHARYBDOTOXIN
TRAM-34
5-HYDROXYDECANOIC ACID SODIUM SALT
CLOFILIUM TOSYLATE
Gabapentin-lactam
PAXILLINE
N-(4-PHENYLSULFONYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANAMIDE
APAMIN
Honey
apamin receptor
APAMIN, ALEXA FLUOR(R) 488 CONJUGATE
APAMIN, BODIPY(R) FL CONJUGATE
APAMIN (DRY ICE)
Kca2.2, SK2, Kcnn2, SKCa2 (Apamin-Sensitive Small Conductance Ca2+ -dependent K+ Channel), Rabbit anti-Rat, WB/IH
ANTI-POTASSIUM CHANNEL SK2 (APAMIN-SENSITIVE CONDUCTANCE CA2+-DEPENDENT K+ CHANNEL, KCA2, KCNN2, SKCA2)
APAMIN, [125I]-HIS18-NH2