Sinomenine
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Sinomenine 속성
- 녹는점
- 180 °C (dec.)(lit.)
- 알파
- D26 -71° (c = 2.1 in alc)
- 끓는 점
- 466.98°C (rough estimate)
- 밀도
- 1.2012 (rough estimate)
- 굴절률
- 1.5000 (estimate)
- 저장 조건
- Store at +4°C
- 용해도
- Soluble to 65 mg/mL (197.33 mM) in DMSO
- 산도 계수 (pKa)
- 9.72±0.40(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- Merck
- 13,8620
- InChIKey
- YMEVIMJAUHZFMW-VUIDNZEBSA-N
- LogP
- 1.245 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn | ||
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위험 카페고리 넘버 | 45-46-23/24/25-36/37/38-20/21/22-48/20/22-40-22-63 | ||
안전지침서 | 53-22-26-36/37/39-45-36/37-24/25 | ||
유엔번호(UN No.) | 1544 | ||
WGK 독일 | 3 | ||
RTECS 번호 | QD2170000 | ||
F 고인화성물질 | 9 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29399990 | ||
독성 | LD50 orally in mice: 580 mg/kg (Fu) |
그림문자(GHS): | ||||||||||||||||||||||||||||||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Sinomenine MSDS
(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
Sinomenine C화학적 특성, 용도, 생산
개요
Isolated by Ohta from Cocculus diversifolius DC., this alkaloid forms colourless crystals from MeOH. It is stated to possess a powerful reflex action and to be aspasm stimulant, finally causing paralysis and death in toxic doses. It is also said to suppress the hypotensive action of dihydroxyphenylethanolethylamine.물리적 성질
Appearance: acicular crystals (crystallized from benzene). Solubility: soluble in ethanol, acetone, chloroform, and dilute alkali; slightly soluble in water, ether, and benzene. Melting point: 219–221?°C. Specific optical rotation:?– 71° (c?=?2.1, ethanol). Its hydrochloride, crystallization (water or ethanol), decomposed at 278?°C.?Its hydroiodide, needle crystal (crystallized from water), decomposed at 272?°C.?Its picrate, which is yellow needle crystal, decomposed at 176?°C.?Sinomenine is sensitive to light and heat to decompose.역사
The chemical structure of sinomenine is composed of four rings, A, B, C, and D, similar to the structure of morphine. Ring A is a benzene ring, and ring B is a half-chair-shaped, six-member ring. The C ring is a twisted-chair-type, sixmember ring that has an a, β-unsaturated ketone structure attached to the B ring. The D ring is a nitrogen-containing, sixmember ring under the B ring. Its structure is shown below; the current structural modification of sinomenine is mainly focused on the A/C active group.Based on the transformation of the A ring, it was found that the 1-substituted formyl derivative of sinomenine showed the strongest inhibitory effect on the inflammatory response of the mouse ear. The 4-substituted p-chlorobenzoyl-sinomenine has the strongest anti-inflammatory and analgesic activity. The biotransformation and chemical synthesis were also used to prepare the di-sinomenine derivatives linked by carbon and carbon, which was stronger than that of sinomenine and had a strong inhibitory effect on cell inflammatory factors. Sinomenine derivatives of the C ring with a pyrazine ring have a strong inhibitory effect on T, B lymphocyte proliferation reaction, which can be used for the preparation of immunomodulatory drugs. The transformation of C ring carbonyl yielded a series of shift alkali derivatives, with strong anti-inflammatory and analgesic effects. These attempts are important for the development of new drugs.
용도
weak abortifacient, immunosuppressant, analgesic, antiinflammatory; LD50 (po) 580 mg/kg; (ip) 285 mg/kg(mouse)Indications
It is mainly used for the treatment of rheumatoid arthritis and other types of rheumatism and arrhythmia in clinical.생물학적 활성
Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ -opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro .Clinical Use
The treatment of rheumatism and rheumatoid arthritis is one of the most important clinical applications of sinomenine. Sinomenine is particularly suitable for the treatment of arrhythmia caused by organic heart disease. Sinomenine is used for the treatment of glomerular disease, which can reduce urinary protein and relieve hematuria symptoms, and the side effects were significantly lower than that of tripterygium glycoside tablets, which are commonly used in clinical practice. In addition, sinomenine can significantly inhibit renal interstitial fibrosis and the production of tissue growth and growth factor TGF-β1. Sinomenine can significantly delay the development of chronic renal failure and effectively treat ankylosing spondylitis.Purification Methods
Crystallise the salt from water (1g/1.5mL) or EtOH. The free base [115-53-7] M 329.4, has m 161o (from EtOH) (and again at 182o) after crystallisation from *C6H6, and [] D -78.9o (c 1, EtOH). The picrate has m 159-162o(dec) (from H2O). [Beilstein 21 II 470, 21 III/IV 6670.]참고 문헌
Ohta., Ber. ges. Physiol., 33, 352 (1925)Ohta, Kitasato., Arch. expo Med., 6, 259, 283 (1925)
Raymond-Hamet., Compt. rend. Soc. Biol., 125, 509 (1937)
Sinomenine 준비 용품 및 원자재
원자재
준비 용품
Sinomenine 공급 업체
글로벌( 339)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Standard Technology Co., Ltd. | 18502101150 |
ft-sales@nature-standard.com | CHINA | 1923 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Sinomenine 관련 검색:
다이메톡시다이페닐 실레인 1,1-디메톡시에탄 디메틸아민 디메톡시메탄 디메틸 카보네이트 디메톡시디메틸실란 1,2-사이클로헥산디온 산소, 냉각된 액체
2,6-Dimethoxybenzaldehyde
Metformin
EC 1.1.1.28
CHLOROPHOSPHONAZO III
(S)-(+)-1-METHYL-3-PHENYLPROPYLAMINE
4-METHYL-4-PHENYLPENTAN-2-ONE
6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALENE
(R)-2-AMINOTETRALIN
2,4-Dimethylpiperidine
Sinomenine Stem P.E