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10-Hydroxycamptothecin

10-Hydroxycamptothecin 구조식 이미지
카스 번호:
19685-09-7
상품명:
10-Hydroxycamptothecin
동의어(영문):
SN38;HCPT;Ampule;10-HCPT;NSC 107124;HYDROCAMPTOTHECINE;hydroxy-camptotheci;Irinotecan USP RC A;HYDROXYCAMPTOTHECIN;10-HYDROCAMPTOTHECIN
CBNumber:
CB4445430
분자식:
C20H16N2O5
포뮬러 무게:
364.35
MOL 파일:
19685-09-7.mol

10-Hydroxycamptothecin 속성

녹는점
265-270°C
끓는 점
820.7±65.0 °C(Predicted)
밀도
1.60
저장 조건
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
산도 계수 (pKa)
8.93±0.40(Predicted)
InChIKey
HAWSQZCWOQZXHI-FQEVSTJZSA-N
CAS 데이터베이스
19685-09-7(CAS DataBase Reference)

안전

안전지침서 24/25
HS 번호 29349990

10-Hydroxycamptothecin C화학적 특성, 용도, 생산

개요

DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways. (S)-10-hydroxy-Camptothecin is an inhibitor of topoisomerase I originally isolated from the Chinese tree C. acuminata. It is a member of the camptothecin family that demonstrates less toxicity than its parent compound. (S)-10-hydroxy-Camptothecin has strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM). In vitro treatment of human HepG2 cells with 5-20 μM (S)-10-hydroxy-camptothecin results in cell cycle arrest at the G2/M phase.

화학적 성질

Yellow Solid

용도

A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy

10-Hydroxycamptothecin 준비 용품 및 원자재

원자재

준비 용품


10-Hydroxycamptothecin 공급 업체

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