Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem 구조식 이미지
카스 번호:
335166-00-2
상품명:
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
동의어(영문):
Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
CBNumber:
CB44813761
분자식:
C19H21Br2ClFN3
포뮬러 무게:
505.65
MOL 파일:
335166-00-2.mol

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem 속성

용해도
Soluble to 5 mM in DMSO

안전

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem C화학적 특성, 용도, 생산

일반 설명

A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC50 = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC50 = 2.5 μM).

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem 준비 용품 및 원자재

원자재

준비 용품


Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem 공급 업체

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