Digitoxin
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Digitoxin 속성
- 녹는점
- 240 °C (dec.)(lit.)
- 알파
- D20 +4.8° (c = 1.2 in dioxane)
- 끓는 점
- 654.47°C (rough estimate)
- 밀도
- 1.0971 (rough estimate)
- 굴절률
- 17 ° (C=2, CHCl3)
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름: 용해성
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 13.50±0.70(Predicted)
- 색상
- 하얀색
- 수용성
- 3.9mg/L(25℃)
- Merck
- 14,3163
- BRN
- 76678
- 안정성
- 흡습성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 23/25-33-39/23/24/25-23/24/25-11 | ||
안전지침서 | 45-36/37-16 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 1 | ||
WGK 독일 | 3 | ||
RTECS 번호 | IH2275000 | ||
F 고인화성물질 | 3-10 | ||
TSCA | Yes | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 2938900000 | ||
유해 물질 데이터 | 71-63-6(Hazardous Substances Data) | ||
독성 | LD50 in guinea pigs, cats (mg/kg): 60.0, 0.18 orally (Foerster) |
Digitoxin C화학적 특성, 용도, 생산
개요
Digitoxin is the most powerful and reliable of the glucosides which have been extracted from digitalis leave. It is a cardiac glycoside (CG). It is a cardiotonic drug, which exhibits cardiac and anti-cancer properties. Digitoxin inhibits nuclear factor kappa B (NF-κB) signaling. It is used to treat congestive heart failure and cardiac arrhythmia. Digitoxin prevents microtubule formation.화학적 성질
White Solid용도
Digitoxin has been used as a labeled drugs for binding sites on human serum albumin (HSA). It has also been used to test its anti-transmissible gastroenteritis virus (TGEV) activity.Indications
Digitoxin (Dig) is an FDA approved drug for the treatment of cardiac disease.Digitoxin is used for the treatment of heart failure, especially in people with impaired kidney function. It is also used to treat certain kinds of heart arrhythmia, such as atrial fibrillation.
Digoxin is used to treat heart failure and abnormal heart rhythms (arrhythmias). It also helps the heart work better and control heart rate. Digoxin may be used after a heart attack. This medication comes in various forms: tablet, capsule, or pediatric elixir (liquid). It is available under the brand names Lanoxin, Cardoxin, Digitek, Digox, and Lanoxicaps.
일반 설명
Odorless white or pale buff microcrystalline powder. Used as a cardiotonic drug.건강위험
Material is bioactive and capable of causing cardiac arrythmias and electrolyte imbalances that may be fatal. Death is due to ventricular fibrillation or cardiac standstill. Material has a high toxicity hazard rating; it may cause death or permanent injury after a very short exposure. It is classified as super toxic; an estimated single lethal dose is 3-10 mg.화재위험
When heated to decomposition, DIGITOXIN emits acrid smoke and irritating fumes.Safety Profile
A deadly poison by most routes. Human systemic effects: arrhythmias, cardiomyopathy, EKG changes, nausea or vomiting, paresthesia, pulse rate increase, thrombocytopenia. Human reproductive effects by ingestion: reduced viability of newborn. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. See also DIGITALIS.Purification Methods
Digitoxin crystallises from MeOH, aqueous EtOH with 0.5 to 1 H2O and from H2O as the dihydrate. It also crystallises from CHCl3/Et2O as anhydrous crystals. The hydrate dehydrates at 120o/vacuum. Its solubility is 2.5% in CHCl3, 1.7% in EtOH, 0.25% in EtOAc, and 0.001% in H2O; and has E1cm 202.5 at 219-220nm (50% EtOH). [Stoll et al. Helv Chim Acta 37 1134 1954, Demoen & Janssen J Am Pharm Assoc 42 635 1953, Beilstein 18 IV 1478.]Digitoxin 준비 용품 및 원자재
원자재
Dry acetone
엔-아밀에테르
아세트산 납
황화 수소
D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-4-O-[2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-β-D-ribo-hexopyranosyl]-3-O-[(1,1-dimethylethyl)dimethylsilyl]-
5-Hexyne-2,3-diol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 2-benzoate, (2R,3R,4S)-
D-ribo-Hex-1-enitol, 1,5-anhydro-2,6-dideoxy-3,4-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-
준비 용품
Digitoxin 공급 업체
글로벌( 219)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20291 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 |
info@antaichem.com | CHINA | 9641 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |