ChemicalBook >제품 카탈로그 >BI 882370

BI 882370

BI 882370 구조식 이미지

카스 번호:: 1392429-79-6

상품명:: BI 882370

동의어(영문):: CS-2615;BI 882370;BI882370;BI-882370;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide

CBNumber:: CB53358255

분자식:: C28H33F2N7O2S

포뮬러 무게:: 569.67

MOL 파일:: 1392429-79-6.mol

속성

안전

용도

공급 업체 41

BI 882370 속성

끓는 점: 649.6±65.0 °C(Predicted)

밀도: 1.37±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)

물리적 상태: 결정성 고체

산도 계수 (pKa): 5.48±0.10(Predicted)

색상: Off-white to gray

안전

BI 882370 C화학적 특성, 용도, 생산

개요

BI-882370 is an orally bioavailable RAF inhibitor with IC₅₀ values of 0.8, 0.8, and 0.6 nM for B-RAF^V600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC₅₀s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.

BI 882370 준비 용품 및 원자재

원자재

준비 용품

BI 882370 공급 업체

글로벌( 41)공급 업체

공급자	전화	이메일	국가	제품 수	이점
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5225	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4334	55
BOC Sciences	16314854226	info@bocsci.com	United States	9926	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8014	62